Education

Fellowship
Allergy-Immunology, Medical Univ of South Carolina College of Medicine, 1985
Residency
Internal Medicine, University of Stellenbosch Faculty of Medicine, 1982
Internship
Internal Medicine, University of Stellenbosch Faculty of Medicine, 1977
Degree
MD, University of Stellenbosch Faculty of Medicine, 1975

Medical Board Certifications

Allergy & Immunology
American Board of Allergy and Immunology, 1991
Internal Medicine
American Board of Internal Medicine, 1989

State License

A47814
  • About Me

    About Me

    Andre Nel is a tenured Professor and practicing allergist/immunologist at UCLA. He runs the Cellular Immunology Activation Laboratory in the UCLA Jonsson Comprehensive Cancer Center

    Academic/Professional Appointments

    • Chief, Division of NanoMedicine at the David Geffen School of Medicine at UCLA
    • Director of the UC Center for the Environmental Impact of Nanotechnology (CEIN)
    • Director of the UCLA Asthma and Immunology Disease Center
    • Co-Director of the Southern California Particle Center
    • Co-Director of the UCLA Nanomachine Center.

    Dr. Nel obtained a Doctorate in Medicine (Ph.D. equivalent) from the University of Stellenbosch, Cape Town RSA, in 1986.

    Dr. Nel is a member of the ASCI, AAAAI, AAI and the Western Association of Physicians. He served as Chair of the Allergy, Immunology, and Transplantation Research Committee, one of the NIAID Study Sections for the review of Training Grants.

    Links

  • Locations

    UCLA Allergy & Immunology

    (primary location)
    Address
    200 UCLA Medical Plaza
    Suite B365
    Los Angeles, California 90095
    Phone
    310-825-6011
  • Education

    Medical Board Certifications

    Allergy & Immunology
    American Board of Allergy and Immunology, 1991
    Internal Medicine
    American Board of Internal Medicine, 1989

    Education

    Fellowship
    Allergy-Immunology, Medical Univ of South Carolina College of Medicine, 1985
    Residency
    Internal Medicine, University of Stellenbosch Faculty of Medicine, 1982
    Internship
    Internal Medicine, University of Stellenbosch Faculty of Medicine, 1977
    Degree
    MD, University of Stellenbosch Faculty of Medicine, 1975
  • Research

    Research Interest

    (i) Nanomedicine and Nanobiology, including nanomaterial therapeutic devices and the study of nanomaterial properties that lead to biocompatible and biohazardous interactions in humans and the environment.

    (ii) The role of air pollutants in asthma, with particular emphasis on the role of ultrafine particle-induced oxidative stress in the generation of airway inflammation and asthma.

    The research is funded by personal RO1 grants from the NIH, the NIAID-funded Asthma and Immunology Disease Clinical Research Center, an EPA STAR award, a $24 million NSF award for a NSF Science Engineering Center. Dr Nel is Director of the UC Center for the Environmental Impact of Nanotechnology (CEIN), Director of the UCLA Asthma and Immunology Disease Center, Co-Director of the Southern California Particle Center, and Co-Director of the UCLA Nanomacchine Center. The Nanomacchine Center (four co-PI’s) develops and utilizes smart nanoparticle delivery systems that can target and control drug release at cancer and disease sites. The mission of the multi-campus UC CEIN is to develop an early warning system for nanomaterial hazards and safe design, particularly as it relates to inteactions with biological systems and ecological life forms.

    Publications

    Recent Representative Publications
    1. Xiao, M. Wang, N. Li, J. A. Loo, A. E. Nel, "Use of Proteomics to Demonstrate a Hierarchical Oxidative Stress Response to Diesel Exhaust Particles in a Macrophage Cell Line", J. Biol. Chem. 278, 50781-50790 (2003).
    2. N. Li, C. Sioutas, A. Cho, D. Schmitz, C. Misra, J. Sempf, T. Oberley, J. Froines, and A. Nel, "Particulate Air Pollutants, Oxidative Stress and Mitochondrial Damage", Environ. Health Perspect. 111, 455-460 (2003).
    3. A. Nel. Atmosphere. Air pollution-related illness: Biomolecular effects of particles.   Science 308: 804  (2005).
    4. Nel, T. Xia, L. Maëdler, and N. Li, "Toxic Potential of Materials at the Nanolevel?"  Science 311, 622-627 (2006).
    5. T. Xia, M. Kovochich, J. Brant, M. Hotze, J. Sempf, T. Oberley, C. Sioutas, J.I. Yeh, M.R. Wiesner, and A.E. Nel, "Comparison of the Abilities of Ambient and Manufactured Nanoparticles to Induce Cellular Toxicity According to an Oxidative Stress Paradigm".  Nanoletters 6, 1794-1807 (2006).
    6. Gong, K.W., Zhao, W., Li, N., Barajas, B., Kleinman, M., Sioutas, C., Horvath, S., Lusis, A.J., Nel A., and Araujo, J.A. Air-pollutant chemicals and oxidized lipids exhibit genome-wide synergistic effects on endothelial cells. Genome Biol. (2007). 8(7):R149
    7. Xia, T., Kovochich, M., Liong, M., Zink, J.I., and Nel A.E. Cationic nanoparticle toxicity depends on cell-specific endocytic and mitochondrial injury pathways. ACS Nano. 2: 85-96 (2008).
    8. Araujo, J.A., Barajas, B., Kleinman, M., Xuping Wang, X., Bennett, B.J., Gong, K.W., Navab, M., Harkema , J., Sioutas, C., Aldons J. Lusis, A.J., Nel, A.E. Ambient particulate pollutants in the ultrafine range promote early atherosclerosis and systemic oxidative stress. Circulation Research. 102:589-96. (2008).
    9. Chatila, T.A, Li, N., Garcia-Lloret, M., Kim, H-J., and Nel, A.E. T cell effector pathways in Allergic Diseases: Transcriptional Mechanisms and Therapeutic Targets. J. Allergy Clin. Immunol. 121: 812-23. (2008).
    10. Li, N., Xia, T., Nel, A.E.  The role of oxidative stress in ambient particulate matter-induced lung diseases and its implications in the toxicity of engineered nanoparticles.  Free Radical Biology & Medicine. 44:1689-99. (2008).
    11. Zhang, L., Wang, M., Kang, X., Boontheung, P., Li, N., Nel, A.E., and Loo, J.A.  Oxidative stress and asthma:  N-acetylcysteine inhibits increased expression of proteins related to lung inflammation from ovalbumin-challenged mice. J. Proteome Research. 8:1631-8 (2009).
    12. Nel, A.E., Maedler, L., Velegol, D., Xia, T., Hoek, E.M., Somasundaran, P., Klaessig, F.,  Castranova, V., and Thompson, M.Understanding biophysicochemical interactions at the nano-bio interface. Nature Materials.  8:543-57 (2009).
    13. Li, N., Wang, M.,. Bramble, L.A., Schmidt, D., Sioutas, C.,. Harkema,, J.R.,  Cho, A., Nel, A.E. Establishment of an Animal Allergen Sensitization Model in which the Adjuvant Effect of Ambient Particulate Matter is Closely Reflected by Particulate Oxidant Potential. Environ Health Perspect. 117:1116-23 (2009).
    14. Xia, T., Li, N., and Nel, A.E.  Potential health impact of nanoparticles. Annual Review of Public Health. 30:21.1-21.14 (2009).
    15. Xia, T., Kovochich, M., Liong, M., Meng, H., Kabehie, S., George, S., Zink, J.I., Nel, A.E. Polyethyleneimine Coating Enhances the Cellular Uptake of Mesoporous Silica Nanoparticles and Allows Safe Delivery of siRNA and DNA Constructs. ACS Nano. Sep 9. [Epub ahead of print] (2009).
    16. Nel, A.E., Maedler, L., Velegol, D., Xia, T., Hoek, E.M., Somasundaran, P., Klaessig, F.,  Castranova, V., and Thompson, M.Understanding biophysicochemical interactions at the nano-bio interface. Nat Mater. 8:543-57 (2009)

    Link to the PubMed site.

  • News & Awards

    In the News

    Awards

    • 2008-2013 Director and PI of the NSF and EPA-funded National Science Engineering Center, Center for the Environmental Impact of Nanotechnology (CEIN)
    • 2009 Distinguished Professor, Foreign Member Chinese Academy of Sciences
    • 1998-present Best Doctors in America (Peer selected inclusion)
    • 2007 John Salvaggio Memorial Lectureship and Honorary Award for outstanding service to the specialty and science of Allergy and Immunology, International AAAAI convention