Education

Degree
PhD, UCLA School of Medicine Dept of Neurobiology (MC 176318), 2011
Fellowship
Reproductive Endocrinology, UCLA School of Medicine, 2007
Residency
Obstetrics & Gynecology, UCLA School of Medicine, 2004
Internship
Obstetrics & Gynecology, UCLA School of Medicine, 2001
Degree
MD, USC School of Medicine, 2000

Medical Board Certifications

Reproductive Endocrinology
American Board of Obstetrics and Gynecology, 2012
Obstetrics & Gynecology
American Board of Obstetrics and Gynecology, 2005

Gender

Male

State License

A79484
  • About Me

    About Me

    Dr. John Kuo has two doctorate degrees (M.D. and Ph.D.) and is double board-certified in Reproductive Endocrinology and Infertility and Obstetrics and Gynecology. He has been a full-time Assistant Professor at the David Geffen School of Medicine at the University of California at Los Angeles (UCLA) since 2007. He has trained and mentored numerous Reproductive Endocrinology and Infertility doctors at UCLA. Dr. Kuo is nationally recognized among the best Infertility doctors in the United States. For his outstanding clinical abilities, excellent patient reviews, new research discoveries, and medical publications, Dr. Kuo has been honored by U.S. News & World ReportÆs ôAmericaÆs Top Doctorö (2012 and 2013), Los Angeles MagazineÆs "Southern California Super Doctors" (2010, 2011, 2012 and 2013), ConsumerÆs Research Council of AmericaÆs "AmericaÆs Top Obstetricians and Gynecologists" (2009, 2010, 2011, 2012 and 2013), Avvo.comÆs ôSuperb Doctor û Rated 10 out of 10ö (2011 and 2012), Vitals.comÆs ôPatientsÆ Choice Awardö (2012), Vitals.comÆs ôMost Compassionate Doctorö (2012), and Avvo.comÆs ôPatientsÆ Choice Awardö (2012).

    Dr. John Kuo's extensive 19 year education started with a Bachelor of Science (B.S.) degree with Academic Honors from Columbia University, a top Ivy-League school. He then earned a Medical Doctor (M.D.) degree from the Keck School of Medicine at the University of Southern California (USC). Dr. Kuo continued his medical training with an internship and residency in Obstetrics and Gynecology (Ob/Gyn) at the David Geffen School of Medicine at UCLA, followed by a fellowship in Reproductive Endocrinology and Infertility (REI) at UCLA. He then joined the UCLA faculty specializing in Reproductive Endocrinology and Infertility. Dr. Kuo is dedicated to providing top quality personalized medical care to his patients. He has been the Oncofertility Director at UCLA since January 2011, which is the fertility field dedicated to preserving the reproductive potential of cancer patients and survivors. His commitment to teaching at UCLA includes multiple Grand Rounds lectures, Graduate level course instructor, fellow physician training, resident physician training, medical student teaching, and medical presentations to the community.

    Dr. John Kuo also earned a Doctor of Philosophy (Ph.D.) degree in Neuroscience at UCLA. He has extensive knowledge and research experience in studying the brain and its functions. The reason is that the human menstrual cycle is actually controlled by the brain. Dr. Kuo's current research in the field of Neuroendocrinology involves understanding hormonal control of ovulation, estrogen effects on brain function, and estrogen receptor signaling. He has been awarded the Women's Reproductive Health Research (WRHR) Grant and the Reproductive Scientist Development Program (RSDP) Grant, which are prestigious physician-scientist research programs from the National Institutes of Health (NIH).

    UCLA Titles/Positions:

    • Assistant Professor
    • Oncofertility Director
    • Director of Kuo Research Laboratory

    Medical Board Licensure/Certifications:

    • Reproductive Endocrinology and Infertility, American Board of Obstetrics and Gynecology, 2012
    • Obstetrics and Gynecology, American Board of Obstetrics and Gynecology, 2005
    • Physician and Surgeon, Medical Board of California, 2002

    Education/Degrees:

    • Doctor of Philosophy (Ph.D.), University of California, Los Angeles, 2011
    • Reproductive Endocrinology and Infertility (Fellowship), University of California, Los Angeles, 2007
    • Obstetrics and Gynecology (Residency), University of California, Los Angeles, 2004
    • Obstetrics and Gynecology (Internship), University of California, Los Angeles, 2001
    • Medical Doctor (M.D.), University of Southern California, 2000
    • Bachelor of Science (B.S.), Columbia University, 1993

    Additional Areas of Expertise/Clinical Interests:

    • In Vitro Fertilization (IVF)
    • Fertility Preservation (Due to Cancer or Advancing Age)
    • Surgical and Medical Treatment of Infertility and Pregnancy Loss
    • Donor Oocyes / Donor Sperm / Gestational Surrogate
    • Preimplantation Genetic Diagnosis and Screening of Embryos
    • Irregular Menstrual Cycles

    Professional Society Memberships:

    • American Society for Reproductive Medicine
    • Society for Reproductive Endocrinology and Infertility
    • Society for Assisted Reproductive Technology
    • American College of Obstetricians and Gynecologists
    • Society for Neuroscience

    Link: Free In Vitro Fertilization (IVF) Class at UCLA

  • Locations

    UCLA Department of Obstetrics and Gynecology

    (primary location)
    Address
    200 UCLA Medical Plaza
    Suite 220
    Los Angeles, California 90095
    Phone
    310-794-7274
  • Education

    Medical Board Certifications

    Reproductive Endocrinology
    American Board of Obstetrics and Gynecology, 2012
    Obstetrics & Gynecology
    American Board of Obstetrics and Gynecology, 2005

    Education

    Degree
    PhD, UCLA School of Medicine Dept of Neurobiology (MC 176318), 2011
    Fellowship
    Reproductive Endocrinology, UCLA School of Medicine, 2007
    Residency
    Obstetrics & Gynecology, UCLA School of Medicine, 2004
    Internship
    Obstetrics & Gynecology, UCLA School of Medicine, 2001
    Degree
    MD, USC School of Medicine, 2000
  • Clinical Interests
    • Abnormal Breast Milk
    • Hirsutism & Masculinization
    • Hysteroscopy
    • In Vitro Fertilization
    • Infertility
    • Laparoscopy
    • Menopause
    • Recurrent Pregnancy Loss
    • Reproductive Endocrinology
    • Tubal Reversal
  • Research

    Publications

    Publications:
    1. Dominguez R, Dewing P, Kuo J, Micevych P. Membrane-initiated estradiol signaling in immortalized hypothalamic N-38 neurons. Steroids. In Press.
    2. Kuo J, Micevych P. Neurosteroids, trigger of the LH surge. The Journal of Steroid Biochemistry and Molecular Biology. 2012 Aug;131(1-2):57-65.
    3. Kuo J. Membrane estrogen receptor-alpha interacts with metabotropic glutamate receptor 1a to stimulate intracellular calcium release and progesterone synthesis in female hypothalamic astrocytes. Ph.D. dissertation, University of California at Los Angeles. May 27, 2011.
    4. Kuo J, Hamid N, Bondar G, Dewing P, Clarkson J, Micevych P. Sex differences in hypothalamic astrocyte response to estradiol stimulation. Biology of Sex Differences. 2010 Nov 22;1(1):7(1-9).
    5. Kuo J, Hamid N, Bondar G, Prossnitz ER, Micevych P. Membrane estrogen receptors stimulate intracellular calcium release and progesterone synthesis in hypothalamic astrocytes. The Journal of Neuroscience. 2010 Sept 29;30(39)12950-12957.
    6. Micevych P, Bondar G, Kuo J. Estrogen actions on neuroendocrine glia. Neuroendocrinology. 2010 Jun;91(3):211-222.
    7. Bondar G, Kuo J, Hamid N, Micevych P. Estradiol-induced estrogen receptor-alpha trafficking. The Journal of Neuroscience. 2009 Dec 2;29(48):15323-15330.
    8. Kuo J, Hariri OR, Micevych P. An interaction of oxytocin receptors with metabotropic glutamate receptors in hypothalamic astrocytes. Journal of Neuroendocrinology. 2009 Dec;21(12):1001-1006.
    9. Micevych P, Kuo J, Christensen A. Physiology of membrane oestrogen receptor signaling in reproduction. Journal of Neuroendocrinology. 2009 Mar;21(4):249-256.
    10. Kuo J, Hariri OR, Bondar G, Ogi J, Micevych P. Membrane estrogen receptor-alpha interacts with metabotropic glutamate receptor 1a to mobilize intracellular calcium in hypothalamic astrocytes. Endocrinology. 2009 Mar;150(3):1369-1376.
    11. Jain JK, Kuo J. Pregnancy outcomes with increased clomiphene citrate dose. Gynecological Endocrinology. 2004 Sept;19(3):141-145.
    12. Jain JK, Nicosia AF, Nucatola DL, Lu JJ, Kuo J, Felix JC. Mifepristone for the prevention of breakthrough bleeding in new starters of depo-medroxyprogesterone acetate. Steroids. 2003 Nov;68(10-13):1115-1119.
    13. Fassett MJ, Bohn Y, Kuo J, Wing DA. Longitudinal evaluation of activated protein C resistance among normal pregnancies of Hispanic women. American Journal of Obstetrics & Gynecology. 2000 Jun;182(6):1433-1436.
    14. Jain JK, Kuo J, Mishell DR Jr. A comparison of two dosing regimens of intravaginal misoprostol for second-trimester pregnancy termination. Obstetrics & Gynecology. 1999 Apr;93(4):571-575.

    Book Chapters:

    1. Kuo J. Case #7 - Hypothyroidism; Case #12 - Contraception: Depo-Provera; and Case #16 - Menopause: Osteoporosis Prevention and Treatment. In: Azziz R, ed. McGraw-Hill Specialty Review: Obstetrics and Gynecology: Cases, Questions, and Answers. New York, NY: McGraw-Hill, 2007.
    2. Rapkin AJ, Kuo J. Neurotransmitter Physiology: The Basics for Understanding Premenstrual Syndrome. In: O'Brien PMS, Rapkin AJ, Schmidt PJ, eds. The Premenstrual Syndromes: PMS and PMDD. Boca Raton, FL: Taylor & Francis, 2007.

    Abstracts:

    1. Kuo J, Chen C, Micevych P. Estradiol signaling regulates de novo progesterone synthesis in hypothalamic astrocytes. Poster presentation at the 42th Annual Meeting of the Society for Neuroscience, Oct. 13-17, 2012, New Orleans, Louisiana.
    2. Micevych P, Kuo J. Astrocyte steroidogenesis and estrogen positive feedback on GnRH neurons. Oral presentation at the 2012 Federation of American Societies for Experimental Biology Science Research Conferences: Integration of Genomic and Non-Genomic Steroid Receptor Actions, July 29 - August 3, 2012, Snowmass Village, Colorado.
    3. Kuo J, Hamid N, Bondar G, Micevych P. Membrane ERa interacts with mGluR1a to stimulate progesterone synthesis in hypothalamic astrocytes. Oral presentation at the 58th Annual Meeting of the Society for Gynecological Investigation, Mar. 16-19, 2011, Miami Beach, Florida.
    4. Kuo J, Hamid N, Bondar G, Micevych P. Sex differences in astrocytic response to estradiol stimulation. Poster presentation at the 40th Annual Meeting of the Society for Neuroscience, Nov. 13-17, 2010, San Diego, California.
    5. Micevych P, Dominguez R, Dewing P, Kuo J. Membrane initiated estradiol signaling in immortalized hypothalamic neurons. Poster presentation at the 40th Annual Meeting of the Society for Neuroscience, Nov. 13-17, 2010, San Diego, California.
    6. Kuo J, Hamid N, Bondar G, Micevych P. Estradiol-induced progesterone synthesis in hypothalamic astrocytes requires rapid interaction between membrane ERa and mGluR1a. Poster presentation at the 39th Annual Meeting of the Society for Neuroscience, Nov. 17-21, 2009, Chicago, Illinois.
    7. Bondar G, Kuo J, Hamid N, Micevych P. Estradiol-induced estrogen receptor-a trafficking. Poster presentation at the 39th Annual Meeting of the Society for Neuroscience, Nov. 17-21, 2009, Chicago, Illinois.
    8. Dominguez R, Kuo J, Christensen A, Micevych P. Estradiol regulates levels of membrane ERa in hypothalamic neurons. Poster presentation at the 39th Annual Meeting of the Society for Neuroscience, Nov. 17-21, 2009, Chicago, Illinois.
    9. Micevych P, Bondar G, Kuo J, Dominguez R. Estradiol regulation of membrane estrogen receptor and its role in reproduction. Oral presentation at the 5th International Meeting of Steroids and Nervous System, Feb. 13-18, 2009, Torino, Italy.
    10. Kuo J, Hamid N, Bondar G, Micevych PE. Membrane estradiol receptors interact with metabotropic glutamate receptors to induce progesterone synthesis in hypothalamic astrocytes. Poster presentation at the 38th Annual Meeting of the Society for Neuroscience, Nov. 15-19, 2008, Washington, D.C.
    11. Micevych P, Christensen A, Hamid N, Kuo J. Physiology of membrane estrogen receptor signaling. Oral presentation at the US/Japan Neurosteroid Symposium 2008, Sept. 8-11, 2008, Gifu, Japan.
    12. Kuo J, Hariri OR, Bondar G, Ogi J, Shung MS, Micevych PE. Membrane estradiol receptors interact with metabotropic glutamate receptors in hypothalamic astrocytes. Poster presentation at the 2008 NIH/NICHD WomenÆs Reproductive Health Research Symposium, Jun. 1-3, 2008, Rochester, New York.
    13. Kuo J, Hariri OR, Bondar G, Ogi J, Shung MS, Micevych PE. Membrane estradiol receptors interact with metabotropic glutamate receptors in hypothalamic astrocytes. Oral presentation at the 55th Annual Meeting of the Society for Gynecological Investigation, Mar. 26-29, 2008, San Diego, California.
    14. Hariri OR, Bondar G, Kuo J, Micevych PE. Estradiol Mobilization of Intracellular Calcium in Hypothalamic Astrocytes Requires ERa and mGluR1a Interaction. Poster presentation at the 37th Annual Meeting of the Society for Neuroscience, Nov. 3-7, 2007, San Diego, California.
    15. Trivax BS, Huang A, Manipalviratn S, Kuo J, DeCherney AH, Wu TJ. The relationship of luteal phase progesterone levels and pregnancy outcomes in in-vitro fertilization-embryo transfer (IVF-ET) cycles. Poster presentation at the 62st Annual Meeting of the American Society for Reproductive Medicine, Oct. 21-25, 2006, New Orleans, Louisi
  • News & Awards

    Awards

    Clinical Awards:

    Research Awards:

    • Reproductive Scientist Development Program (RSDP) K12 Grant, National Institutes of Health and Bayer HealthCare Pharmaceuticals, 2010 – 2012
    • Women's Reproductive Health Research (WRHR) K12 Grant, National Institutes of Health, 2007 – 2010

    Grand Rounds Speaker:

    • UCLA Medical Center, Department of Obstetrics and Gynecology, ôOncofertility: fertility preservation options for cancer patients.ö û 6/29/12
    • UCLA Medical Center, Department of Obstetrics and Gynecology, ôInfertility: Evaluation and Treatment Options.ö û 2/24/12
    • Cedars-Sinai Medical Center, Department of Obstetrics and Gynecology, ôInteraction of membrane estradiol receptors with metabotropic glutamate receptors.ö û 8/8/07

    Invited Speaker:

    • The Simms/Mann û UCLA Center for Integrative Oncology, Insights Into Cancer 2013, ôParenthood after cancer diagnosis: fertility options from diagnosis to survivorship.ö û 4/9/13
    • UCLA Medical Center, Department of Pediatrics, Division of Hematology and Oncology Conference, ôFertility Preservation and Assisted Reproduction.ö û 2/1/11

    UCLA Ob/Gyn Residency and REI Fellowship Clinical Lectures:

    • Fellowship Lecture, Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, ôNeuroendocrinology, Part Iö û 10/24/11, 3/25/13
    • Fellowship Lecture, Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, ôNeuroendocrinology, Part IIö û 11/21/11
    • Residency Lecture, Department of Obstetrics and Gynecology, ôGalactorrhea/Hyperprolactinemiaö û 10/28/11

    UCLA Medical School Courses:

    • Ob/Gyn clerkship, ôClimacteric and Infertilityö û 1/16/08, 3/11/08, 2/22/11, 6/21/11, 7/28/11, 9/8/11, 10/20/11, 11/17/11, 2/10/12, 2/28/12, 5/17/12, 6/25/12, 8/10/12
    • Ob/Gyn clerkship, ôHistory, Examination, Pap Smear and Cultures, Personal Interaction and Communication Skills, Preventive Care and Health Maintenance, and Diagnosis and Management Planö û 7/13/07

    UCLA Graduate Level Course:

    • Neurobiology M227 (Neuroendocrinology of Reproduction), ôReproductive Senescence in Women: Follicular Reserve, Perimenopause, and Menopauseö (2 hours) û 3/7/08, 3/1/10, 2/27/12

    Community Presentation:

    • UCLA Fertility and Reproductive Health Center, Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, In Vitro Fertilization Class at UCLA: ôThe CoupleÆs Guide to IVFö û 1/26/11, 4/6/11, 6/8/11, 7/13/11, 8/24/11, 10/26/11, 2/8/12, 4/25/12, 6/27/12, 8/8/12

    Research Presentations:

    • UCLA Medical Center, Department of Obstetrics and Gynecology, Research and Recognition Day, Specialty Training and Advanced Research Fellows Scientific Session, ôMembrane estrogen receptor-alpha signaling in hypothalamic astrocytes.ö û 6/15/12
    • UCLA Medical Center, Women's Reproductive Health Research Center and Department of Obstetrics and Gynecology, Research Presentation, ôThe role of membrane-associated estrogen receptor-alpha in estrogen positive feedback.ö û 1/27/12
    • Bayer-NICHD Reproductive Scientist Development Program, ScholarÆs Research Conference, Boulder, Colorado, ôMembrane-associated estrogen receptor-alpha signaling in hypothalamic astrocytes is required for estrogen positive feedback in rodents.ö û 9/23/11
    • UCLA Medical Center, Specialty Training and Advanced Research program, ôMembrane estrogen receptor-alpha signaling in hypothalamic astrocytes.ö û 7/14/11
    • UCLA Medical Center, Department of Obstetrics and Gynecology, Research and Recognition Day, Specialty Training and Advanced Research Fellows Scientific Session, ôMembrane-associated estrogen receptor-alpha signaling in hypothalamic astrocytes is required for estrogen positive feedback in rodents.ö û 6/17/11
    • Bayer-NICHD Reproductive Scientist Development Program Symposium, Miami Beach, Florida, ôMembrane estrogen receptor-alpha interaction with metabotropic glutamate receptor 1A is required for rapid estradiol signaling in hypothalamic astrocytesö û 3/17/11
    • UCLA Medical Center, Department of Obstetrics and Gynecology, Research and Recognition Day, Specialty Training and Advanced Research Fellows Scientific Session, ôMembrane ER-alpha signaling and trafficking in hypothalamic astrocytes.ö û 6/18/10
    • UCLA Medical Center, Brain Research Institute, Laboratory of Neuroendocrinology, Research Presentation, ôMembrane estrogen receptor-alpha interacts with metabotropic glutamate receptor 1a to mediate rapid estradiol signaling in hypothalamic astrocytes.ö û 6/4/10
    • UCLA Medical Center, Department of Obstetrics a