Neurology, UCLA School of Medicine, 1996
Neurology, University of Virginia Medical Center, 1994
Internal Medicine, Riverside Methodist Hospitals, 1991
MD, Ohio State University College of Medicine, 1990

Medical Board Certifications

American Board of Psychiatry and Neurology, 1998

State License

  • About Me

    About Me

    Preferred Name: Paul M. Vespa, MD, FCCM, FAANS

    Professor In Residence of Neurosurgery and Neurology and Director of the Neurocritical Care Program. As a neurointensive care specialist, Dr. Vespa focuses on critical care for the treatment of neurosurgical and stroke patients. Dr. Vespa is a Diplomate of the UCNS in Neurocritical Care and a Diplomate of the American Board of Pyschiatry and Neurology.


    • Professor of Neurosurgery and Neurology, UCLA School of Medicine
    • Director of Neurocritical Care


    • United Council of Neurologic Subspecialties, Chair Person
    • Neurocritical Care Society, Board of Directors, Executive Committee
    • University of California Brain Injury Association
    • National Stroke Association
    • American Heart Association - Section on Stroke
    • NACABI Founding Member, North American Consortium of Acute Brain Injury
    • American Academy of Neurology (AAN)
    • AAN Section of Emergency and Critical Care Neurology
    • AAN Section on Clinical Neurophysiology
    • AAN Section on Stroke
    • Society of Critical Care Medicine
    • California Chapter of The Society of Critical Care Medicine 


  • Locations


    (primary location)
    300 Stein Plaza
    Suite 420
    Los Angeles, California 90095
  • Education

    Medical Board Certifications

    American Board of Psychiatry and Neurology, 1998


    Neurology, UCLA School of Medicine, 1996
    Neurology, University of Virginia Medical Center, 1994
    Internal Medicine, Riverside Methodist Hospitals, 1991
    MD, Ohio State University College of Medicine, 1990
  • Clinical Interests
    • Brain Trauma
    • Electroencephalogram (EEG)
    • Head Trauma
    • Hydrocephalus
    • Intracerebral Hemorrhage
    • Subarachnoid Hemorrhage
  • Research

    Research Interest

    Traumatic Brain Injury, Intracerebral Hemorrhage, Coma, Seizures, Brain Imaging (PET and MRI), Stroke


    1. Vespa, PM, Nuwer, MR, Nenov, V, Ronne-Engstrom, E, Hovda, DA, Martin, NA, Becker, DP. Increased incidence and impact of nonconvulsive and convulsive seizures after traumatic brain injury as detected by continuous EEG in the intensive care unit. J Neurosurg 91:750-760, 1999. PMID: 10541231
    2. Vespa P, Hovda DA, Nenov V, Boscardin J, Nuwer MR, Martin NA, Glenn T, Bergsneider M, Kelly D, Becker D. Early and persistent impaired percent alpha variability on continuous electroencephalographic monitoring is predictive of poor outcome after traumatic brain injury. J Neurosurg 2002, 97:84-91. PMID: 12134937
    3. Vespa P, McArthur D, Glenn T, O’Phelan K, Etchepare M, Kelly D, Bergsneider M, Martin NA, Hovda DA. Persistently reduced levels of extracellular glucose early after traumatic brain injury correlate with poor outcome at six months: A microdialysis study. J Cereb Blood Flow Metab 2003, 23:865-877. PMID: 12843790
    4. Vespa P, Bleck TP. Neurogenic pulmonary edema and other causes of impaired oxygenation after aneurismal Subarachnoid hemorrhage. Neurocritical Care 2004, 2:1-14. PMID: 16174911
    5. Vespa P, McArthur D, Alger J, O’Phelan K, Glenn T, Bergsneider M, Martin NA, Hovda DA. Regional Heterogeneity of Brain Metabolism using Cerebral Microdialysis: Concordance with Magnetic Resonance Spectroscopy and Positron Emission Tomography. Brain Pathology 2004, 14:210-214. PMID: 15193034
    6. Vespa P, Bergsneider, M, Hattori, N, Wu, C, Huang, S-C, Martin, NA, Glen, TP, Hovda, DA. Metabolic crisis without brain ischemia after traumatic brain injury: A combined microdialysis and positron emission tomography study. J Cereb Blood Flow Metab 2005 25:763-74. PMID: 15716852
    7. Vespa P, Boonyaputthikul, P, McArthur, DL, Miller, C, Etchepare, M, Bergsneider, M, Glenn, T, Martin, NA, Hovda, DA. Intensive insulin therapy reduces microdialysis glucose values without altering glucose utilization or improving the lactate/pyruvate ratio after traumatic brain injury. Critical Care Medicine 2006 34(3):850-6. PMID: 16505665
    8. Vespa, P, Ophelan, K, McArthur, DA, Miller, C, Glenn, TC, Martin, NA, Hovda, DA. Pericontusional Brain Tissue Exhibits Persistent Elevation of Lactate/Pyruvate Ratio Independent of Cerebral Perfusion Pressure (Critical Care Medicine. Crit Care Med. 2007 35:1153-1160. PMID: 17334254
    9. Hebb MO, McArthur DL, Alger J, Etchepare M, Glenn TC, Bergsneider M, Martin N, Vespa PM. Impaired percent alpha variability on continuous electroencephalography is associated with thalamic injury and predicts poor long-term outcome after human traumatic brain injury. J Neurotrauma. 2007 Apr;24(4):579-90. PMID: 17439342
    10. Vespa, PM, Miller, C, McArthur, D, Eliseo, M, Etchepare, M, Hirt, D, Glenn, TC, Martin, N, Hovda, DA. Nonconvulsive electrographic seizures after traumatic brain injury result in a delayed, prolonged increase in intracranial pressure and metabolic crisis. Crit Care Medicine 35:1-7, 2007. PMID: 18074483
    11. Marcoux J, McArthur DA, Miller C, Glenn TC, Villablanca P, Martin NA, Hovda DA, Alger JR, Vespa PM. Persistent metabolic crisis as measured by elevated cerebral microdialysis lactate-pyruvate ratio predicts chronic frontal lobe brain atrophy after traumatic brain injury. Crit Care Med. 2008. Oct;36(10):2871-7. PMID: 18766106
    12. Hamilton R, Xu P, Asgari S, Kasprowicz M, Vespa P, Bergsneider M, Hu X. Forecasting intracranial pressure elevation using pulse waveform morphology. Conf Proc IEEE Eng Med Biol Soc. 2009;1:4331-4.
    13. Xu Y, McArthur DL, Alger JR, Etchepare M, Hovda DA, Glenn TC, Huang S, Dinov I, Vespa PM. Early nonischemic oxidative metabolic dysfunction leads to chronic brain atrophy in traumatic brain injury. Cereb Blood Flow Metab. 2009 Dec 23. PMID: 20029449
    14. Vespa PM, McArthur DL, Xu Y, Eliseo M, Etchepare M, Dinov I, Alger J, Glenn TP, Hovda D. Nonconvulsive seizures after traumatic brain injury are associated with hippocampal atrophy. Neurology. 2010, 75:792-8. PMID. 20805525
    15. Lakshmanan R, Loo JA, Drake T, Leblanc J, Ytterberg AJ, McArthur DL, Etchepare M, Vespa PM. Metabolic crisis after traumatic brain injury is associated with a novel microdialysis proteome.Neurocrit Care. 2010 Jun;12(3):324-36.
    16. Lee SJ, Saver JL, Liebeskind DS, Ali L, Ovbiagele B, Kim D, Vespa P, Froehler M, Tenser M, Gadhia J, Starkman S. Safety of intravenous fibrinolysis in imaging-confirmed single penetrator artery infarcts. Stroke. 2010 Nov;41(11):2587-91. Epub 2010 Oct 14.
    17. Kim S, Scalzo F, Bergsneider M, Vespa P, Martin N, Hu X. Noninvasive Intracranial Pressure Assessment based on Data Mining Approach using Nonlinear Mapping Function. IEEE Trans Biomed Eng. 2010 Nov 22. [Epub ahead of print].
    18. Shi ZS, Liebeskind DS, Loh Y, Saver JL, Starkman S, Vespa PM, Gonzalez NR, Tateshima S, Jahan R, Feng L, Miller C, Ali LK, Ovbiagele B, Kim D, Duckwiler GR, Viñuela F; UCLA Endovascular Stroke Therapy Investigators. Predictors of subarachnoid hemorrhage in acute ischemic stroke with endovascular therapy. Stroke. 2010 Dec;41(12):2775-81.
    19. Loh Y, Liebeskind DS, Towfighi A, Vespa P, Starkman S, Saver JL, Gonzalez NR, Tateshima S, Jahan R, Shi ZS, Viñuela F, Duckwiler GR. Preprocedural basal ganglionic infarction increases the risk of hemorrhagic transformation but not worse outcome following successful recanalization of acute middle cerebral artery occlusions. World Neurosurg. 2010 Dec;74(6):636-640.
    20. Kim S, Hu X, McArthur D, Hamilton R, Bergsneider M, Glenn T, Martin N, Vespa P. Inter-subject correlation exists between morphological metrics of cerebral blood flow velocity and intracranial pressure pulses. Neurocrit Care. 2011 Apr;14(2):229-237.
    21. Marder VJ, Blinc A, Gruber T, Tratar G, Sabovic M, Starkman S, Jahan R, Duckwiler G, Vinuela F, Tateshima S, Liebeskind D, Ovbiagele B, Ali L, Kim D, Gonzalez N, Vespa PM, Saver JL. Comparison of plasmin with recombinant tissue-type plasminogen activator in lysis of cerebral thromboemboli retrieved from patients with acute ischemic stroke. Stroke. 2011 Aug;42(8):2222-2228.
    22. Asgari S, Bergsneider M, Hamilton R, Vespa P, Hu X. Consistent changes in intracranial pressure waveform morphology induced by acute hypercapnic cerebral vasodilatation. Neurocrit Care. 2011 Aug;15(1):55-62.
    23. Irimia A, Chambers MC, Alger JR, Filippou M, Prastawa MW, Wang B, Hovda D, Gerig G, Toga AW, Kikinis R, Vespa PM, Van Horn JD. Comparison of acute and chronic traumatic brain injury using semi-automatic multimodal segmentation of MR volumes. J Neurotrauma. 2011 Jul 25.
    24. Wijman CA, Smirnakis SM, Vespa P, Szigeti K, Ziai WC, Ning MM, Rosand J, Hanley DF, Geocadin R, Hall C, Le Roux PD, Suarez JI, Zaidat OO; For the First Neurocritical Care Research Conference Investigators. Research and Technology in Neurocritical Care. Neurocrit Care. 2011 Jul 28. [Epub ahead of print].
    25. Asgari S, Vespa P, Bergsneider M, Hu X. Lack of consistent intracranial pressure pulse morphological changes during episodes of microdialysis lactate/pyruvate ratio increase. Physiol Meas. 2011 32:1639-1651. PMID: 21904021.
  • News & Awards

    In the News


    • Board of Directors of Unified Council of Neurologic Subspecialities
    • SCCM Neuroscience Award Winner
    • Fellow of the American College of Critical Care Medicine