Education

Fellowship
Cytopathology, UCLA School of Medicine, 1998
Residency
Pathology, UCLA School of Medicine, 1997
Degree
MD, Wright State University School of Medicine, 1992

Medical Board Certifications

Cytopathology
American Board of Pathology, 1998
Anatomic Pathology & Clinical Pathology
American Board of Pathology, 1997

State License

G77815
  • About Me

    About Me

    Academic Title:  Associate Professor of Pathology and Laboratory Medicine

    Department Title:  Chief of Breast Pathology

    Specialty:  Surgical Pathology, Cytopathology, Breast Pathology, Gynecologic Pathology

    Sophia K. Apple M.D. is a Chief of Breast Pathology and Professor who has served on the UCLA School of Medicine faculty since she joined the Department of Pathology in 2002. She has published over 50 original articles, numerous abstracts, and book chapters in the topic of breast cancer. She is an author of the leading textbook titled "The Breast Imaging" through Elsevier Publisher. She is a national and international speaker in breast pathology.She currently serves on the editorial board of 5 medical journals.Dr. Apple received her M.D. at Wright State University Medical Center in 1992. She received her Masters degree in Biochemistry at New York University and earned her B.S. in Biochemistry at New York University. She was trained in her anatomical and clinical pathology residency and Cytopathology fellowship at UCLA.She worked as a partner physician at Southern Kaiser Permanente group at Woodland Hills for more than four years and received an award for the most outstanding physician of the year at 2001, just after 3 years of practice. She is also a Cytopathology Fellowship Director at UCLA. Dr. Apple's research focuses on factors associated with the development of breast cancer and features associated with breast cancer biomarkers. Her consultations are praised nationwide for their clinical insights and diagnostic acumen.

    Links

  • Locations

    UCLA Pathology & Lab Medicine

    (primary location)
    Address
    10833 Le Conte Avenue
    Suite 13-188 CHS
    Los Angeles, California 90095
    Phone
    310-825-9288
  • Education

    Medical Board Certifications

    Cytopathology
    American Board of Pathology, 1998
    Anatomic Pathology & Clinical Pathology
    American Board of Pathology, 1997

    Education

    Fellowship
    Cytopathology, UCLA School of Medicine, 1998
    Residency
    Pathology, UCLA School of Medicine, 1997
    Degree
    MD, Wright State University School of Medicine, 1992
  • Research

    Publications

    1. Konecny Gottfried E, Pauletti Giovanni, Untch Michael, Wang He-Jing, Möbus Volker, Kuhn Walther, Thomssen Christoph, Harbeck Nadia, Wang Ling, Apple Sophia, Jänicke Fritz, Slamon Dennis J Association between HER2, TOP2A, and response to anthracycline-based preoperative chemotherapy in high-risk primary breast cancer.. Breast cancer research and treatment. 2010; 120(2): 481-9.
    2. Apple Sophia K, Moatamed Neda A, Finck Rachel H, Sullivan Peggy S Accurate classification of sentinel lymph node metastases in patients with lobular breast carcinoma.. Breast (Edinburgh, Scotland). 2010; 120(2): .
    3. Behjatnia Bita, Sim Julie, Bassett Lawrence W, Moatamed Neda A, Apple Sophia K. Does size matter? Comparison study between MRI, gross, and microscopic tumor sizes in breast cancer in lumpectomy specimens. International journal of clinical and experimental pathology. 2010; 3(3): 303-9.
    4. Apple Sophia K, Lowe Alarice C, Rao P Nagesh, Shintaku I Peter, Moatamed Neda A Comparison of fluorescent in situ hybridization HER-2/neu results on core needle biopsy and excisional biopsy in primary breast cancer.. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. 2009; 22(9): 1151-9.
    5. Apple Sophia K, Moatamed Neda A, Lai Chi K, Bhuta Sunita Sebaceous adenoma of the parotid gland: a case report with fine needle aspiration findings and histologic correlation.. Acta cytologica. 2009; 53(4): 419-22.
    6. Moatamed, Naini, Fathizadeh, Estrella, Apple A correlation study of diagnostic fine-needle aspiration with histologic diagnosis in cystic neck lesions.. Diagnostic cytopathology. 2009; 37: 720-726.
    7. Sullivan Peggy S, Apple Sophia K. Should histologic type be taken into account when considering neoadjuvant chemotherapy in breast carcinoma?. The breast journal. 2009; 15(2): 146-54.
    8. Day Christina, Moatamed Neda, Fimbres Amber M, Salami Nikki, Lim Susan, Apple Sophia K. A retrospective study of the diagnostic accuracy of fine-needle aspiration for breast lesions and implications for future use.. Diagnostic cytopathology. 2008; 36(12): 855-60.
    9. Haines G Kenneth, Wiley Elizabeth, Susnik Barbara, Apple Sophia K, Frkovic-Grazio Snjezana, Reyes Carolina, Goldstein Lynn C, Dadmanesh Farnaz, Gown Allen M, Nadji Mehrdad, Bracko Matej, Tavassoli Fattaneh. A HER2 in well differentiated breast cancer: is testing necessary?. Breast cancer research and treatment. 2008; 112(3): 551-6.
    10. Lin Kevin, Eradat Jilbert, Mehta Niraj H, Bent Chris, Lee Steve P, Apple Sophia K, Bassett Lawrence W. Is a short-interval postradiation mammogram necessary after conservative surgery and radiation in breast cancer?. International journal of radiation oncology, biology, physics. 2008; 72(4): 1041-7.
    11. Naini Bita V, Apple Sophia K, Presley Michelle, Moatamed Neda A.  A correlation study on diagnostic endoscopic ultrasound-guided fine-needle aspiration of lymph nodes with histological and clinical diagnoses, the UCLA Medical Center experience.. Diagnostic cytopathology. 2008; 36(7): 460-6.
    12. Moatamed Neda A, Apple Sophia K. Extensive sampling changes T-staging of infiltrating lobular carcinoma of breast: a comparative study of gross versus microscopic tumor sizes.. The breast journal. 2007; 12(6): 511-7.
    13. Bassett Lawrence W, Mahoney Mary C, Apple Sophia K. Interventional breast imaging: current procedures and assessing for concordance with pathology.. Radiologic clinics of North America. 2007; 45(5): 881-94, vii.
    14. Ra Seong H, Fishbein Michael C, Baruch-Oren Tamar, Shintaku Peter, Apple Sophia K, Cameron Robert B, Lai Chi K Mucinous adenocarcinomas of the thymus: report of 2 cases and review of the literature.. The American journal of surgical pathology. 2007; 31(9): 1330-6.
    15. Burge Chandra N, Chang Helena R, Apple Sophia K. Do the histologic features and results of breast cancer biomarker studies differ between core biopsy and surgical excision specimens?. Breast (Edinburgh, Scotland). 2006; 15(2): 167-72.
    16. Prati Raquel, Apple Sophia K, He Jianbo, Gornbein Jeffrey A, Chang Helena R. Histopathologic characteristics predicting HER-2/neu amplification in breast cancer.. The breast journal. 2006; 11(6): 433-9.
    17. Apple Sophia K. Variability in gross and microscopic pathology reporting in excisional biopsies of breast cancer tissue.. The breast journal. 2006; 12(2): 145-9.
    18. Apple Sophia K. Invasive ductal carcinoma with tissue neutrophilia: a distinct entity?. Breast (Edinburgh, Scotland). 2004; 13(6): 519-21.
    19. Sartippour Maryam R, Rao Jian Yu, Apple Sophia, Wu Debbie, Henning Susanne, Wang Hejing, Elashoff Robert, Rubio Rosalio, Heber David, Brooks Mai N. A pilot clinical study of short-term isoflavone supplements in breast cancer patients.. Nutrition and cancer. 2004; 49(1): 59-65.
    20. Zhang Liping, Maul Raymond Scott, Rao JianYu, Apple Sophia, Seligson David, Sartippour Maryam, Rubio Rosalio, Brooks Mai N Expression pattern of the novel gene EG-1 in cancer. Clinical cancer research : an official journal of the American Association for Cancer Research. 2004; 10(10): 3504-8.