Preferred Name: Steve
Stephen Young grew up in Topeka, Kansas, and then obtained an undergraduate degree in history from Princeton University. Following medical school at Washington University in St. Louis, he obtained internal medicine training at UCSF and cardiology training at UCSD. He then did postdoctoral research training in lipoprotein metabolism at UCSD. He then became an investigator at a research institute with UCSF, where he studied the molecular genetics of apolipoprotein B, a cholesterol-carrying protein in the plasma. Along the way, he became an expert in using genetically modified mice for deciphering gene function.
Currently, his laboratory focuses on two areas û plasma triglyceride metabolism and diseases of the nuclear envelope. Along with his UCLA colleagues, he identified an endothelial cell protein, GPIHBP1, which is required for shuttling lipoprotein lipase (LPL) to the capillary lumen. Without GPIHBP1, LPL remains mislocalized in the interstitial spaces, resulting in severe hypertriglyceridemia. In recent years, Dr. Young has also worked on the role of the nuclear lamina in the developing brain. He has also worked on strategies to treat progeria, a disease caused by a genetic defect in prelamin A.