Dr. Manoj Sarma (Assistant Researcher, UCLA Radiological Sciences) was recently awarded a two-year R21 grant for his project entitled "Brain Connectivity, Cerebral metabolism and Neuropsychology in HIV Youths" by NINDS/NIH.
Although earlier neuroimaging studies investigated brain connectivity and neurochemical changes in HIV adults, brain connectivity changes have not been studied in perinatally HIV-infected youths. Also, the relationship of cerebral metabolic disturbance to neurocognitive and functional abnormalities in HIV has not been well delineated. Dr. Sarma's proposed work combining resting state functional Magnetic Resonance Imaging (MRI) with semi-LASER based 3D Magnetic Resonance Spectroscopic Imaging (MRSI) will impact the field with a better understanding of the functional neural and metabolic correlates in perinatally infected youths.
Dr. Sarma is working with Dr. Albert Thomas, Director of MR Spectroscopy at UCLA Radiology and a pioneer of various multi-dimensional MRSI techniques including 2D Localized correlated MR spectroscopy (L-COSY). This project will be in collaboration with Dr. Margaret Keller at Pediatric Infectious Diseases unit, Harbor-UCLA Medical Center. Dr. Sarma's specialty area of research includes development of novel in-vivo imaging techniques involving MRS/MRI for the study of brain, development and implementation of fast imaging techniques. He has been working on MRI/MRSI pulse sequence development, signal processing, and data analysis within interdisciplinary teams in various projects like HIV-infected youths, obstructive sleep apnea, Hepatitis C, hepatic encephalopathy, prostate cancer, and Diabetes.
Congratulations to Dr. Sarma and his research team on their significant achievement!