The UCLA Department of Radiation Oncology is committed to a greater understanding of radiation therapy. Our Radiation Oncology Research Lab faculty members and students collaborate with colleagues around the university, and the world to advance their unique areas of research.
Our research labs are devoted to conducting translational research, a type of combined clinical and basic science investigation in which knowledge learned from the basic research in the laboratory with genes, cells, or animals is translated into therapeutic intervention in human subjects.
Our overall research mission is to continue this proven track record of success, to support innovation and to increase the clinical impact of research outputs through strengthened collaboration and knowledge sharing.
Frank Pajonk, MD, PhD
Our laboratory has a long-standing interest in signal transduction and the role of the 26S proteasome in cancer. We were among the first working with prospectively identified cancer stem cells and since then we have made seminal discoveries including the intrinsic radioresistance of breast cancer stem cells and its underlying mechanisms, developed innovative new techniques to image, track and target cancer stem cells in vitro and in vivo and uncovered fundamental differences in the metabolic state of cancer stem cells and their progeny. The Pajonk Lab >
Ke Sheng, PhD, DABR, FAAPM
MRI is playing an increasingly important role in radiotherapy by providing kenetic, functional and real time monitoring of the tumor and normal tissue for improved radiotherapy accuracy and efficacy. We are interested in solvng problems assocaited with MRI guided radiotherapy, including fast MRI acquisition, automated organ delineation, deformable registration and utilization of functional MRI information for adaptive radiotherapy and outcome assessment. The Sheng Lab >
Erina Vlashi, PhD
The Vlashi laboratory is committed to pursuing projects with a high potential for translation to clinical practice for cancer patients, with a particular interest in improving the effect of radiation therapy (RT) for resistant tumors, such as glioblastoma multiforme and pancreatic ductal adenocarcinoma. The main research interests of our group focus on the metabolism of cancer cells, specifically on cancer cells with a cancer-initiating phenotype (cancer stem/initiating cells, CSC/CICs) and the changes induced by radiation therapy that ultimately lead to resistance. The Vlashi Lab >