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UCLA Rheumatology

Research

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Research

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UCLA Division of Rheumatology conducts cutting-edge biomedical and health-related research studies that include both interventional and observational studies. Our clinical studies are sponsored/funded by National Institute of Health (NIH), pharmaceutical companies, and/or non-profit medical institutions/organizations.

Treatment/Interventional studies are those in which the research subjects are assigned to a treatment or intervention and their outcomes are measured.

Observational studies are those in which individuals are observed and their outcomes are measured by the study investigators.

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Current Clinical Studies

Rheumatoid Arthritis

Systemic Lupus Erythematosis

Scleroderma

Psoriatic Arthritis & Ankylosing Spondylitis

Myositis

Sjogren's Syndrome

Vasculitis

Gout

Connective Tissue Disease-Interstitial Lung Disease (CTD-ILD)


If you would like to get more information on any studies please call us at (310) 825-0096 or email rheumresearch@mednet.ucla.edu.

If you are interested in finding out more information of a particular study, please contact the study personnel.

Study Type

Title of Study

RHEUMATOID ARTHRITIS
Treatment/Interventional

TARGET: To compare the effects on vascular inflammation of TNFi + MTX versus triple therapy in subjects with RA who are inadequate responders to MTX using FDG PET/CT as a tool for detecting vascular (arterial) inflammation.

Principal Investigators
Christina Charles-Schoeman, MD, MS

For more information contact Jeraldine 310-206-4007 

Observational

Longitudinal Cardiovascular Risk Study of Patients with Rheumatoid Arthritis

Principal Investigators
Christina Charles-Schoeman, MD, MS

For more information contact Jeraldine 310-206-4007

Treatment

StopRA: Study to determine if hydroxychloroquine is safe and effective for the prevention of future onset of RA in people with elevated anti-CCP levels.

Principal Investigators
Maureen McMahon, MD, MS

For more information contact Julia 310-825-6461

Treatment CANNABIS: Cannabis Anonymous Questionnaire in UCLA Rheumatology Patients. Principal Investigators
Veena K. Ranganath, MD, MS, RhMSUS

 
Treatment ACTHAR: Use of ACTHAR in Rheumatoid Arthritis Related Flares. Principal Investigators
Veena K. Ranganath, MD, MS, RhMSUS


UPCOMING STUDIES

Treatment

CANNABIDIOL: Therapeutic Response of Cannabidiol in Rheumatoid Arthritis

Principal Investigators
Veena K. Ranganath, MD, MS, RhMSUS

SYSTEMIC LUPUS ERYTHEMATOSIS
Observational Precise: Looking for inpatient active lupus patients upon initial admission (prior to steroids) to follow longitudinally for disease activity. Principal Investigators
Jennifer King, MD, PhD

For more information contact Samya 310-825-2548
Treatment ALE09: Study to evaluate the efficacy, safety, and tolerability of lenabasum (synthetic cannabinoid) in decreasing pain associated with arthritis or tendonitis in lupus patients. Principal Investigators
Maureen McMahon, MD, MS

For more information contact Julia 310-825-6461
Treatment Eli Lilly JAHZ: Study to determine the effect of baricitinib and standard-of-care therapy on lupus disease activity. Principal Investigators
Jennifer Grossman, MD

For more information contact Julia 310-825-6461
Observational Pro-inflammatory HDL Cholesterol: Evaluating biomarkers of risk for atherosclerosis in lupus. Involves a one-time blood draw. Principal Investigators
Maureen McMahon, MD, MS

For more information contact Lucas 310-825-2598
Treatment IDEAL: Evaluating the value of educational information about the risks and benefits of lupus medications. Implementation of the DEcision-Aid for Lupus in practice settings for shared decision-making. Principal Investigators
Maureen McMahon, MD, MS

For more information contact Julia 310-825-6461
Treatment BMS PAISLEY: A study to evaluate the efficacy and safety of BMS-986165 in improving renal function in lupus nephritis patients who do not adequately respond to mycophenolate mofetil (MMF). Principal Investigators
Maureen McMahon, MD, MS

For more information contact Julia 310-825-6461

UPCOMING STUDIES

Observational GSK Belimumab in Early Lupus: A study to evaluate the effects of belimumab in patients recently diagnosed with lupus. Principal Investigators
Maureen McMahon, MD, MS

For more information contact Julia 310-825-6461
Treatment Amgen AMG570: A study evaluating the safety and efficacy AMG 570 in lupus patients. Principal Investigators
Maureen McMahon, MD, MS

For more information contact Julia 310-825-6461
SCLERODERMA
Treatment BRAVOS ITN075AI: Study of an Investigational Drug, Brentuximab Vedotin, for Diffuse Cutaneous Systemic Sclerosis

Principal Investigator
Suzanne Kafaja, MD

For more information, contact Isabel 310-825-9682

Treatment Cumberland: A Study to Assess the Safety and Efficacy of Ifetroban in Patients with Diffuse Systemic Sclerosis or Systemic Sclerosis-Associated Pulmonary Arterial Hypertension

Principal Investigator
Suzanne Kafaja, MD

For more information, contact Isabel 310-825-9682

Treatment CORBUS JBT101-SSc-002: A study to evaluate efficacy and safety of Lenabasum in diffuse cutaneous Systemic Sclerosis

Principal Investigator
Suzanne Kafaja, MD

For more information, contact Isabel 310-825-9682

Observational (Long-Term Follow-Up) ASSET Long Term Follow-Up: A long term follow-up on ASSET: A study to evaluate subcutaneous abatacept vs. placebo in diffuse cutaneous systemic sclerosis

Principal Investigator
Suzanne Kafaja, MD

For more information, contact Isabel 310-825-9682

Observational GRASP: Genome Research in African American Scleroderma Patients (GRASP)

Principal Investigator
Suzanne Kafaja, MD

For more information, contact Isabel 310-825-9682

Observational SPIN: The Scleroderma Patient-Centered Intervention Network (SPIN) cohort collecting data on a regular basis related to problems likely to be important for many people living with scleroderma

Principal Investigator
Suzanne Kafaja, MD

For more information, contact Isabel 310-825-9682

Observational PI-Initiated: A study to define the differences in IMMUNE RESPONSES in skin from patients with an autoimmune or inflammatory condition

Principal Investigator
Suzanne Kafaja, MD

For more information, contact Isabel 310-825-9682

Treatment SLS III: A combination study of pirfenidone (PFD) with mycophenolate (MMF) for treating scleroderma-related lung disease

Co-Principal Investigator                   

Elizabeth Volkmann, MD, MS 

Co-Investigator                        

Suzanne Kafaja, MD

For more information, contact Isabel 310-825-9682

Treatment SLS III: Mycophenolate vs. Mycophenolate + Pirfenidone for SSc-ILD

Co-Principal Investigator
Elizabeth Volkmann, MD, MS

For more information, contact Paul Lopez or Eileen Callahan 310-794-2466

Treatment Forbius: A novel TGF-beta inhibitor for patients with diffuse cutaneous sclerosis

Principal Investigator
Elizabeth Volkmann, MD, MS

For more information, contact  310-990-3520

Treatment CSL Behring: IVIG for patients with diffuse cutaneous sclerosis

Principal Investigator
Elizabeth Volkmann, MD, MS

For more information, contact  310-990-3520

 Observational SSc Microbiome study: Any patient with systemic sclerosis

Principal Investigator
Elizabeth Volkmann, MD, MS

For more information, contact 310-990-3520

Observational The Gut Microbiome as a Screening Tool for ILD in SSc

Principal Investigator
Elizabeth Volkmann, MD, MS

For more information, contact 310-990-3520

Observational Biomarkers to Predict Treatment Response in SSc-ILD

Principal Investigator
Elizabeth Volkmann, MD, MS

For more information, contact 310-990-3520

Observational CURESSC - Consortium of Universities to REsearch Scleroderma in Southern California

Principal Investigator
Elizabeth Volkmann, MD, MS

For more information, contact 310-990-3520

 Observational Scleroderma Clinical Trial Consortium: The gastrointestinal Microbiome as a Marker of disease Activity in Systemic Sclerosis

Co-Principal Investigator
Elizabeth Volkmann, MD, MS

For more information, contact 310-990-3520

Treatment Galapagos GLPG1690: A study to evaluate the efficacy, safety, and tolerability of orally administered GLPG1690 (ATX inhibitor)

Principal Investigator
Suzanne Kafaja, MD

For more information, contact Isabel 310-825-9682

UPCOMING STUDIES
Treatment Kadmon KD025-209: A study to evaluate the efficacy and safety of KD025 (ROCK2 inhibitor) in subjects with diffuse cutaneous Systemic Sclerosis

Principal Investigator
Suzanne Kafaja, MD

For more information, contact Isabel 310-825-9682

Treatment Eicos ES-301: A study evaluating the safety and efficacy of IV Iloprost in subjects with systemic sclerosis experiencing symptomatic digital ischemic episodes

Principal Investigator
Suzanne Kafaja, MD

For more information, contact Isabel 310-825-9682

Treatment

IgPro10_2001: Study to evaluate the efficacy and safety of IgPro10 (intravenous immunoglobulin, Privigen®) for the treatment of adults with Systemic Sclerosis

Principal Investigator
Suzanne Kafaja, MD

For more information, contact Isabel 310-825-9682

PSORIATIC ARTHRITIS & ANKYLOSING SPONDYLITIS

Treatment

Novartis CAIN457F2354: A study to assess the time course of response to secukinumab on joint inflammation using Power Doppler ultrasonography in patients with active psoriatic arthritis

Principal Investigator
Suzanne Kafaja, MD

For more information, contact Isabel 310-825-9682

MYOSITIS
Observational

 Longitudinal Cohort Study of Patients with Idiopathic Inflammatory Myopathies

Principal Investigators
Christina Charles-Schoeman, MD, MS

For more information contact Jeraldine 310-206-4007

Treatment

 Corbus: Lenabasum for patients with active dermatomyositis

Principal Investigators
Elizabeth Volkmann, MD, MS

For more information contact Paul Lopez or Eileen Callahan 310-794-2466

UPCOMING STUDIES

Treatment/Interventional

 CSL Behring: A study to evaluate the efficacy safety, and pharmacokinetics of IgPro20 (subcutaneous immunoglobulin, Hizentra®) in adults with dermatomyositis (DM)

Principal Investigators
Christina Charles-Schoeman, MD, MS

For more information contact Jeraldine 310-206-4007

SJOGREN'S SYNDROME
Observational

 NGS Sjogren’s: Looking for primary Sjogren’s patients, both seropositive SSA+ or seronegative; especially with parotid swelling

Principal Investigator
Jennifer King, MD

For more information, contact Samya 310-825-2548

VASCULITIS
No Studies at this time
GOUT
No Studies at this time
UPCOMING STUDIES
No Studies at this time
CONNECTIVE TISSUE DISEASE-INTERSTITIAL LUNG DISEASE (CTD-ILD)
Observational CTD-ILD Registry: Any patient with a CTD-ILD Principal Investigators
Elizabeth Volkmann, MD, MS

For more information contact Paul Lopez or Eileen Callahan 310-794-2466

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