Researchers led by a UCLA bioengineer have developed a therapy — based on two types of cells joined into a single unit — that could help strengthen existing treatments for acute myeloid leukemia. One of the cells is a blood platelet that carries a drug that attacks cancer cells; the other is a stem cell that guides the platelet into bone marrow, the spongy tissue inside bone where new blood cells are made and where leukemia begins.
A scanning electron microscope colorized to show the hematopoietic stem cells (purple) and blood platelets (green) joined together. Image: Courtesy of Dr. Zhen Gu
The researchers found that when injected into mice that had acute myeloid leukemia, the combination therapy halted the disease from developing any further. Of the mice that received the treatment, 87.5 percent were cured by 80 days after the combination cells were injected. Those mice also were all resistant to leukemia cells that were reinjected two months after the 80-day period.
Zhen Gu, PhD, professor of bioengineering in the UCLA Henry Samueli School of Engineering who led the study, says the approach could be used in concert with other therapies, such as chemotherapy and stem cell treatment, to improve their effectiveness. Dr. Gu says the approach would have to be tested in human clinical trials and then approved for use before it could be incorporated in treatments for people with leukemia.
Acute myeloid leukemia is a cancer that starts in bone marrow and affects the precursor stem cells to white blood cells, which are a key part of the immune system. The cancer can spread to the bloodstream and other parts of the body. With a compromised immune system, a person with this type of leukemia could die from complications from other diseases.
As a treatment for leukemia, chemotherapy on its own is only moderately effective: Leukemia fails to go into remission in about one-third of patients following chemotherapy, according to the American Cancer Society. And about half of people with the disease who do experience remission initially may have a relapse — typically within two years after treatment — usually because some cancer cells can take shelter in bone marrow, where the chemotherapy can’t reach them.
The UCLA-led research aimed to solve that problem by devising a method to deliver medicine directly into the bone marrow. The approach, which researchers termed “cell combination drug delivery,” is the first to link two different cells together for therapeutic purposes.
In the combined cells, the blood platelets are used to deliver immunotherapy drugs called checkpoint inhibitors (the UCLA researchers used a drug called an anti-PD-1 antibody), which seek out cancer cells and neutralize their defenses. Once that happens, the body’s immune system can “see” and destroy the cancer cells.
The second element of the two-cell combination is a hematopoietic stem cell. Hematopoietic stem cells, or blood stem cells, can find their way into the bone marrow through specific chemical signals — an important ability for the study because cancer cells could be located anywhere in the body.
The researchers plan to continue studying the approach as a potential therapy for leukemia and other diseases.
“Conjugation of Haematopoietic Stem Cells and Platelets Decorated with Anti-PD-1 Antibodies Augments Anti-leukaemia Efficacy,” Nature Biomedical Engineering, October 29, 2018
