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The Cutting Edge

Why Alzheimer’s Meds Rarely Help

Molecular structures of Aß oligomers and Aß fibers.Molecular structures of Aß oligomers and Aß fibers.
Photo: Courtesy of Dr. Zhefeng Guo

The nonprofit Alzheimer’s Association projects that the number of people living with Alzheimer’s disease will soar, from 5 million to 13.8 million by 2050, unless scientists develop new ways to stop the disease. Current medications do not treat Alzheimer’s or stop it from progressing; they only temporarily lessen symptoms, such as memory loss and confusion.

Current Alzheimer’s drugs aim to reduce the amyloid plaques — sticky deposits that build up in the brain — that are a visual trademark of the disease. These plaques are made of long fibers of a protein called amyloid beta, or Aß. Recent studies, however, suggest that the real culprit behind Alzheimer’s may be small Aß clumps, called oligomers, that appear in the brain years before plaques develop.

In unraveling the molecular structure of oligomers, UCLA scientists, led by Zhefeng Guo, PhD, assistant professor of neurology and a member of UCLA’s Brain Research Institute and Molecular Biology Institute, discovered that Aß has a vastly different organization in oligomers than in amyloid plaques. Their finding could shed light on why Alzheimer’s drugs designed to seek out amyloid plaques have no effect on oligomers; the study suggests that the drugs failed in clinical trials because they zero in on plaques and do not work on oligomers. Future studies on oligomers will help speed the development of new drugs specifically aiming at Aß oligomers, the researchers say.

“Teasing Out the Structural Details of an Oligomer Involved in Alzheimer Disease: Structural Insights into Aß42 Oligomers Using Site-directed Spin Labeling,” Journal of Biological Chemistry, June 28, 2013


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IN THIS ISSUE
  • Too Small to Fail
  • Simple Screening Catches Newborn’s Hidden Heart Condition
  • Antihistamines May Pose Risk to Women with Severe Morning Sickness
  • Why Alzheimer’s Meds Rarely Help
  • New Clues to Cause of Human Narcolepsy
  • Exercise after School to Stay Fit
  • Stem-Cell Gene Therapy for Sickle Cell Advances Toward Clinical Trials
  • WALL-E, Meet EVA: Robo-doc Navigates on Its Own
  • Fat Chance: Scientists Accidently Discover Stress-Resistant Stem Cells in Adipose Tissue
  • Doctor-Patient Communication about Dietary Supplements Could Use a Vitamin Boost
  • New Learning Center Will Expand School's Capabilities
  • Nadereh Pourat, PhD
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