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Kidney Transplant Clinical Trials

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Phone: 310-794-7700

A clinical trial is a study conducted with actual patients, usually to evaluate a new treatment. Each study is designed to answer scientific questions and to find new and better ways to help patients.

Ongoing Clinical Trials for Kidney Transplant:


Treatment Study After Kidney Transplant

Lay Title: An investigational treatment study after kidney transplant
Technical Title: Donor Chimerism and Graft Survival Following Combined HLA-Identical Sibling Living Donor Kidney and Hematopoietic Stem Cell Transplantation Utilizing a Conditioning Regimen of Total Lymphoid Irradiation (TLI) and Rabbit Anti-Thymocyte Globulin (rATG)
Disease Type: Males and females ages 18 years and older receiving living donor kidney transplant from an HLA-identical sibling at University of California Los Angeles (UCLA) Medical Center.
Basic information: The purpose of this study is to find out if an investigational treatment will allow kidney transplant recipients to better accept their new kidney and stop immunosuppressive medicines. This study is for kidney transplant recipients who receive a kidney from a sibling donor. The investigational treatment is started after kidney transplant. It begins with a regimen of a drug called rabbit anti-thymocyte globulin (rATG) combined with radiation therapy (known as total lymphoid irradiation, or TLI) to the lymph nodes and spleen. This is followed by an infusion of blood stem cells, which will be donated by the same sibling who donated their kidney. Researchers think that this treatment allows immune cells from the donor and recipient to live side by side, a condition referred to as "mixed chimerism." Mixed chimerism may help create a state of "tolerance" in kidney transplant recipients in which all immunosuppressive medications can be stopped without rejection of the transplanted kidney. This study will test whether (1) the investigational treatment will allow patients to stop immunosuppressive medications after their kidney transplant and (2) if the treatment impacts the rate of kidney rejection and the side effects of immunosuppressive medications.

For detailed eligibility, visit UCLA Health Clinical Trials, or ClinicalTrials.gov.

For More Detailed Information, Contact:

  • Jeffrey Veale, MD, Principal Investigator
  • Dana Levin, Study Coordinator, (310) 794-8893

For information on inclusion and exclusion criteria please call our Clinical Trials Office: 310-206-5930

  • Frequently Asked Questions
  • UCLA Office of Clinical Trials
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