Lay Title: A Study of Radiation Therapy Instead of Surgery for Patients with Large Kidney Tumors
Technical Title: Prospective Study of Interstitial Brachytherapy for Unresectable/Unablatable T1b/T2a Renal Masses
Disease Type: Kidney Cancer
In patients with large kidney tumors unable to undergo surgery, treatment options are limited and include systemic therapy (e.g., drugs), but these do not typically have good outcomes. Types of radiation therapy typically have a much higher rate of tumor control. This study is designed to evaluate the safety and outcomes of modern brachytherapy, a type of radiation therapy.
The purpose of this research study is to test whether interstitial brachytherapy, a procedure that has been employed to successfully manage other genitourinary cancers, can be used to limit the growth of large kidney cancer masses. Brachytherapy temporarily introduces a radiation source (Iridium -192) into or near the tumor to eradicate the cancer cells.
Research Procedures (not a complete list): If you agree to participate in this study, you will undergo a series of physical exams and blood draws to determine whether it is safe for you to receive brachytherapy.
Brachytherapy includes the surgical placement of catheters into or near the tumor, into which a radiation source is placed. Patients will receive brachytherapy once, or in some instances twice, delivered over a period of one day or over two weeks. Some patients may be required to stay overnight in the hospital post-brachytherapy for observation. All subjects will return to their doctors at UCLA for regular, routine safety follow-ups and scans. At some of these follow-up patients will have blood drawn for routine purposes, and sometimes for research purposes.
Eligibility Criteria (not a complete list):
For More Detailed Information, Contact: