Lay Title: GARUDA Study for Prostate Cancer
Technical Title: Germline DNA-based Radiosensitivity Biomarker Influence on Toxicity Following Radiotherapy (GARUDA)
Disease Type: Adenocarcinoma of the prostate
Basic Information: External beam radiation therapy is a routine treatment for men with prostate cancer. This study will provide routine radiation therapy over either 5, 20, or 45 “fractions,” or separate treatments. It is hoped that a simple analysis of the patient’s DNA will determine which treatment schedule may be the most effective while reducing the severity of side effects.
Research Procedures (not a complete list): If you agree to participate in this study, you will receive one of three routine radiation therapy schedules, but first you will have your DNA tested to determine which one may be the most effective with the least side effects. Collecting DNA is a painless procedure, similar to rubbing a Q-tip swab inside of your mouth. The swab kit will be mailed to your home, and we will ask you to collect the DNA sample at home and mail your sample to the laboratory for analysis using a pre-paid mailer.
After receiving radiation therapy, you will return to the UCLA Department of Radiation Oncology for routine follow-up visits approximately one month after treatment, once every three months thereafter for the first year, and then every six months thereafter. These visits will include a brief physical exam and completion of quality of life questionnaires. On occasion, routine blood collected for medical tests, and CT scans or MRIs will take place.
Eligibility Criteria (not a complete list):
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