Prostate Cancer Clinical Trials

Treatment Studies

Clinically Localized

• Active Surveillance for Cancer of the Prostate (ASCAP)
• MIRAGE Protocol for Prostate Cancer
• GARUDA Study for Prostate Cancer

• Targeted Ultrasound Ablation for Treatment  of Localized  Prostate Cancer

Neoadjuvant/adjuvant (before/after your primary cancer treatment)

• Short-Course of Radiotherapy Following Prostatectomy for Men with Advanced Prostate Cancer
• A Study for Men with Prostate Cancer who are Candidates for Radical Prostatectomy

Metastatic, Castration-Sensitive

• Systemic and Directed Therapy for Recurrent Prostate Cancer

Metastatic, Castration-Resistant (mCRPC)

• A Study Using the Research Drug Talazoparib with Enzalutamide to Treat Your Prostate Cancer
• A Study of FOR46 Given Every 21 Days for the Treatment of Your Prostate Cancer
• A Study Using the Research Drug AMG 160 to Treat Your Prostate Cancer
• A New Study to Treat Prostate Cancer in People who have Metastatic Castrate-Resistant Prostate Cancer (mCRPC) and DNA Repair Defects
• KEYNOTE-641: A Study comparing Enzalutamide with or without Pembrolizumab in Metastatic Prostate Cancer
• KEYLYNK-010: A Study comparing Pembrolizumab plus Olaparib versus Abiraterone Acetate or Enzalutamide to treat Metastatic Prostate Cancer

• A Study Evaluating the Safety and Effectiveness of AB928-BasedTreatment Combinations in Patients with Metastatic Castrate Resistant Prostate Cancer (mCRPC) 

• A Study Evaluating the Safety of a new drug (ARV-110) in Patients with Metastatic Castration-Resistant Prostate Cancer

• A Study Assessing the Safety of a new drug (MGC018) in Patients with Solid Tumors

• CheckMate 7DX: A Study comparing Docetaxel with or without Nivolumab in Metastatic Prostate Cancer

Other

• Pembrolizumab with Chemo in Urothelial and Prostate Cancers
• KEYNOTE-991: A Phase 3 Study for Patients with Metastatic Hormone-Sensitive Prostate Cancer (mHSPC)
• Radio-guided Surgery Study: 99mTc-PSMA-I&S in Patients With Prostate Cancer: An Exploratory Biodistribution Study With Histopathology Validation

Imaging Studies

• An imaging study to evaluate the effects of hormonal treatments on prostate cancer imaging with PSMA PET
• An Experimental Imaging Scan to Treat Your Prostate Cancer Recurrence with Radiation Therapy
• Expanded Access Protocol of 68Ga-PSMA-11 for Prostate Cancer PET Imaging (EAP)
• An imaging study of 68Ga-PSMA-11 PET/CT Scan in Impacting Treatment Strategies for Patients with Prostate Cancer (BASKET)
• A randomized imaging study of PSMA PET scan before definitive radiation therapy in patients with unfavorable IR or HR prostate cancer (PSMA PyL dRT)
• A prospective exploratory imaging study of 68Ga-FAPI-46 PET/CT Scan in Patients with Prostate Cancer (FAPI Prostate)

Observational and Biospecimen Studies

• GU Cancer Repository Study
• A Registry for Men with Advanced Prostate Cancer
• Cryoablation Study
• Fusion Biopsy: Prostate Cancer Imaging (Fusion Biopsy Stidy)
• High-intensity Focused Ultrasound Study
• Hypo-fractionated Stereotactic Body Radiotherapy in High Risk Prostate Cancer

Other

• HITCH: Male Veterans Hospitalized Due to COVID-19 Illness