Nestor Fadrique Gonzalez-Cadavid, PhD

EDUCATION

Undergraduate:
M.Sc. in Biochemistry, University of Buenos Aires, Argentina

Medical School:
Ph.D in Biochemistry, University of Buenos Aires, Argentina
Ph.D in Biochemistry, University of London, England

Board Certifications & Fellowships
Research Fellowship, National Council of Scientific Research (Argentina)
Research Fellowship (abroad), National Council of Scientific Research Argentina, to work at the Courtauld Institute of Biochemistry, London University, London, England
Research Fellowship, Welcome Trust (England), to work at the same institution
Senior Research Fellowship, Guggenheim Foundation (USA), to work at the California Institute of Technology, Biology Division, Pasadena, California, USA
Short Training Fellowship, International Union Against Cancer, to work at the City of Hope Medical Center, Division of Biology, Duarte, California, USA
Eleanor Roosevelt Senior Research Fellowship, International Union Against Cancer, to work at UCLA Medical School, Department of Medicine, Los Angeles, California, USA
Senior Research Fellowship, United Nations University, to work at the same institution
Public Health Award, to work at the Population Research Center, Torrance, Ca

RESEARCH AREA

Dr. Gonzalez-Cadavid has made significant research contributions in several fields of cellular and molecular biology approaches to pathophysiology. He focused initially on alterations of collagen deposition with aging, and later on mitochondrial biogenesis and protein synthesis. These studies evolved into the role of mitochondrial DNA and different oncogenes in tumor progression, and after joining the UCLA Department of Urology he focused on topics of urology relevance, mainly androgen dependence of penile growth and erectile function, and the effect of risk factors for erectile dysfunction, such as aging, diabetes, and smoking, on the nitric oxide/cGMP control of the erectile response. His group reported the first demonstration of the correction of erectile dysfunction in an animal model by gene therapy, and more recently showed that long-term continuous administration of nitric oxide donors and PDE5 inhibitors corrects in animal models the underlying corporal and arterial fibrosis associated with aging, diabetes and radical prostatectomy, as well as the fibrotic plaque of Peyronie’s disease. Lately, he has extended those studies to the modulation of multipotent and stem cell differentiation by nitric oxide, cGMP, and myostatin, and its application to the therapy of erectile dysfunction and other forms of urogenital disease and other conditions associated with tissue fibrosis. He is currently funded for some of these studies by NIH, the Department of Defense, and other agencies.

Dr. Gonzalez-Cadavid has a long-standing teaching experience in biochemistry, and molecular and cellular biology courses. He has been particularly devoted to the training of junior biomedical scientists by supervising numerous PhD and MSc students, as well as postdoctoral researchers and physicians, who are now academic faculty in several countries. He serves as reviewer of many journals and member of several academic and research committees, and has three patents awarded.

ACADEMIC AND MEDICAL STAFF APPOINTMENTS

UNIVERSITY POSITIONS
1968/70. Associate Professor, Department of Biochemistry, School of Science, Central University, Caracas, Venezuela
1970/90. Full Professor, Department of Cell Biology, School of Science, Central University, Caracas, Venezuela. Director, Laboratory of Molecular Oncology.
1990-5. Adjunct Associate Professor of Urology, Department of Urology, UCLA School of Medicine, Los Angeles, CA, USA. Joint with appointment at Harbor-UCLA Research and Education Institute.
1993-on. Director, Urology Research Laboratory, Harbor-UCLA Research and Education Institute, Torrance, CA
1995-on Adjunct Professor of Urology, Department of Urology, UCLA School of Medicine, Los Angeles, CA, USA. Currently, Step II
1997-on. Professor of Medicine, Department of Internal Medicine, Division of Endocrinology, Metabolism and Molecular Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, Ca.
2001-on. Director, NIH-RCMI DNA Repository and Molecular Medicine Core, Charles R. Drew University of Medicine and Science, Los Angeles , Ca. Currently, in consideration as NIH-RCMI Molecular Medicine Research Core, sub-contracting LABioMed at Harbor-UCLA.
2004-on. Associate-Director, NIH Program for the Biological Effects of Androgens in Men and Women. Charles R. Drew University/UCLA. Charles R. Drew University of Medicine and Science, Los Angeles , Ca

VISITING FACULTY POSITIONS
1971. Visiting Scientist, Massachusetts Institute of Technology, Division of Biology, Cambridge , Massachusetts , USA
1978-9. Gosney Visiting Associate in Biology, California Institute of Technology, Biology Division, Pasadena , California , USA
1980-1. Visiting Associate in Biology, same institution
1982. Visiting Professor, University of Buenos Aires , Argentina , School of Biochemistry , Buenos Aires , Argentina
1987/88. Visiting Professor, UCLA School of Medicine, Division of Hematology & Oncology, Los Angeles , CA , USA
1988-9. Visiting Scientist, UCLA School of Medicine, Division of Urology, Los Angeles , California , USA

PROFESSIONAL MEMBERSHIP

1966 9. Biochemical Society , Great Britain .
1968 90. Venezuelan Biochemical Society , Venezuela .
1968 90. Venezuelan Association for the Advancement of Science , Venezuela .
1981 8. American Association for the Advancement of Science , USA .
1987 9. Tissue Culture Association, USA .
1989. New York Academy of Sciences , USA ..
1992-on. American Society of Andrology , USA .
1998-on. Endocrine Society , USA
2000-on. Society of Impotence Research (Current: American Society of Sexual Medicine)
2001-on. American Urological Association
2001-on. Society for the Study of Reproduction
2004-on. Society of Sexual Medicine of North America
2006-on. International Society of Sexual Medicine

RESEARCH AND CLINICAL INTERESTS

LINKS

AWARDS AND HONORS

Gold Medal to the top graduate, University of Buenos Aires
Gold Medal to the best Ph.D. thesis, University of Buenos Aires
Harbor-UCLA , Research and Education Institute, award to scientific research by institutional PhDs
2005 Member Department of Defense Study Section
2008-09 Ad hoc member NIDDK UKGD Study Section
2009-13 Member NIDDK UKGD Study Section

PERSONAL

ADDITIONAL INFORMATION

Selected peer-reviewed publications from 2003-2009 (from a list of 159 (Sept 09) on CV). For any update on PubMed use Gonzalez-Cadavid, without initials Read my PubMed publications
Also three patents issued and one under review. List available on request

• Ferrini MG, Magee TR, Vernet D, Rajfer J, Gonzalez-Cadavid NF (2003) Penile neuronal nitric oxide synthase (PnNOS) and its regulatory proteins are present in hypothalamic and spinal cord regions involved in the control of penile erection. J Compar Neurol 458:46-61
• Magee T, Zeller CB, Ferrini M, Davila H, Vernet D, Burnett AL, Rajfer J, González-Cadavid NF (2003) A protein inhibitor of NOS (PIN) is expressed in the rat and mouse penile nerves and co-localizes with penile neuronal NOS (PnNOS) Biol Reprod 68:478-488.
• Berman JR, Almeida FG, Jolin J, Raz S, Chaudhuri G, Gonzalez-Cadavid NF (2003) Androgen receptors, aromatase, and 5--reductase in human vagina: correlation with menopausal status. Fertil Steril, 79:925-931.
• Davila H, Ferrini M, Rajfer J, Gonzalez-Cadavid NF (2003) Fibrin induction of a Peyronie's-like plaque in the rat penile tunica albuginea. A new model for Peyronie's disease. Br J Urol, 91:830-838.
• Reisz-Porszasz S, Bhasin S, Artaza JN, Shen R, Sinha-Hikim I, Houge A, Gonzalez-Cadavid NF (2003) Reduction of skeletal muscle mass in a transgenic mouse that hyperexpresses myostatin in the muscle. Am J Physiol, Am J Physiol, 2003 Oct;285(4):E876-888.
• Ma K, Mallidis C, Bhasin S, Mahabadi V, Artaza J, Gonzalez-Cadavid N, Arias J, Salehian B (2003) Glucocorticoid-Induced Skeletal Muscle Atrophy is Associated with Upregulation of Myostatin Gene Expression. Am J Physiol, 285:E363-371.
• Valente EG, Vernet D, Ferrini MG, Qian A, Rajfer J, Gonzalez-Cadavid NF (2003) PDE L-arginine and PDE inhibitors counteract fibrosis in Peyronie’s plaque and related fibroblast cultures. Nitric Oxide, 9:229-244.
• Singh R, Artaza JN, Taylor WE, ( Gonzalez-Cadavid NF *, Bhasin S*; *: equal contributors) (2003) Androgens stimulate myogenenic differentiation and inhibit adipogenesis in C3H 10T1/2 pluripotent stem cells through an androgen receptor-mediated pathway. Endocrinology, 144:5081-508
• Liu W, Thomas SG, Asa SL, Gonzalez-Cadavid NF, Bhasin S, Ezzat S (2003) Myostatin is a Skeletal Muscle Target of Growth Hormone Anabolic Action. J Clin Endocrin Metabol, 88:5490-5496
• Bhasin S, Taylor W, Singh R, Artaza J, Sinha-hickim I, Jasuja R, Choi H, Gonzalez-Cadavid NF (2003) The mechanisms of androgen effects on body composition: mesenchymal pluripotent cell as the target of androgen action. J Gerontol, 58:M1103-10.
• Ferrini MG, Davila H, Valente EG, ( Gonzalez-Cadavid NF *, Rajfer J*, *equal contributors) (2004) Aging-related induction of inducible nitric oxide synthase (iNOS) is vasculo-protective in the arterial media. Cardiovascular Res ;61:796-805.
• Qian A, Meals R, Rajfer J, Gonzalez-Cadavid NF (2004) Comparison of gene expression profiles between Peyronie's disease and Dupuytren's contracture. Urology, 64:399-404.
• Gonzalez-Cadavid NF , Bhasin S (2004) Role of myostatin in metabolism. Curr Opin Clin Nutr Metabol Care, 7:451-457.
• Gonzalez-Cadavid NF , Rajfer J (2004). Therapy of erectile function: Potential future treatments. Endocrine, 23:167-176.
• Gonzalez-Cadavid NF , Rajfer J (2004) Molecular and cellular aspects of the pathophysiology of Peyronie’s disease. Drug Discovery Today. Disease mechanisms, 1:99-106
• Davila HH, Magee TR, Rajfer J, Gonzalez-Cadavid NF (2004) Gene therapy with the inducible nitric oxide synthase (iNOS) cDNA regresses the fibrotic plaque in an animal model of Peyronie’s disease. Biol Reprod, 71:1568-1577
• Davila HH, Rajfer J, Gonzalez-Cadavid NF (2004) Corporal veno-occlusive dysfunction in the aging rat. evaluation by cavernosometry and cavernosography. Urology, 64:1261-1266.
• Gonzalez-Cadavid NF , Rajfer J (2004) Molecular pathophysiology and gene therapy of aging-related erectile dysfunction. Exptl Gerontol, 39:1705-1712
• Sinha-Hikim I, Taylor WE, Gonzalez-Cadavid NF, Zheng W, Bhasin S (2004) Androgen receptor in human skeletal muscle and cultured muscle satellite cells: Up-regulation by androgen treatment. J Clin Endocr Metabol 89:5245-5255.
• Davila H, Magee TR, Rajfer J, Gonzalez-Cadavid NF (2005). Peyronie's disease is associated with an increase of plasminogen activator inhibitor-1 (PAI-1) at the RNA and protein levels. Urology, 65:645-648
• Hikim AP, Vera Y, Vernet D, Castanares M, Diaz-Romero M, Ferrini M, Swerdloff RS, Gonzalez-Cadavid NF, Wang C (2005) Involvement of nitric oxide-mediated intrinsic pathway signaling in age-related increase in germ cell apoptosis in male brown-norway rats. J Gerontol A Biol Sci Med Sci 60:702-708.
• Artaza JN, Bhasin S, Magee TR, Reisz-Porszasz S, Shen R, Groome NP, Fareez MM, Gonzalez-Cadavid NF (2005) Myostatin inhibits myogenesis and promotes adipogenesis in C3H 10T(1/2) mesenchymal multipotent cells. Endocrinology 146:3547-3557.
• Vernet D, Qian A, Nolazco G, Cantini L, Magee TR, Ferrini MG, Rajfer J, Gonzalez-Cadavid NF (2005) Evidence that osteogenic progenitor cells in the human tunica albuginea may originate from stem cells. Implications for Peyronie’s disease. Biol Reprod, 73:1199-1210.
• Jasuja R, Ramaraj P, Mac RP, Singh AB, Storer TW, Artaza J, Miller A, Singh R, Taylor WE, Lee ML, Davidson T, Sinha-Hikim I, Gonzalez-Cadavid N, Bhasin S (2005) Delta-4-androstene-3,17-dione binds androgen receptor, promotes myogenesis in vitro, and increases serum testosterone levels, fat-free mass, and muscle strength in hypogonadal men. J Clin Endocrinol Metab. 90:855-863.
• Gonzalez-Cadavid NF , Rajfer J (2005) The pleiotropic effects of inducible nitric oxide synthase on the physiology and pathology of penile erection. Curr Pharm Des 11:4041-4046
• Gonzalez-Cadavid NF , Rajfer J (2005) Mechanisms of disease: new insights into the cellular and molecular pathology of Peyronie’s disease. Nature Clin Pract Urol, 2:291-298.
• Saenz de Tejada I, Angulo J, Cellek S, Gonzalez-Cadavid N, Heaton J, Pickard R, Simonsen U (2005) Physiology of erectile function. J Sex Med 1:254-265.
• Saenz de Tejada I, Angulo J, Cellek S, Gonzalez-Cadavid N, Heaton J, Pickard R, Simonsen U (2005) Pathophysiology of erectile dysfunction. J Sex Med 2:26-39.
• Ferrini MG, Nolazco G, Vernet D, Gonzalez-Cadavid NF*, Berman J* (*: equal contributors) (2006) Increased vaginal oxidative stress, apoptosis, and inducible nitric oxide synthase in a diabetic rat model: implications for vaginal fibrosis. Fertil Steril, 86:1152-1163.
• Ferrini MG, Kovanecz I, Nolazco G, Rajfer J, Gonzalez-Cadavid NF (2006) Effects of long-term treatment with vardenafil on the development of the fibrotic plaque in a rat model of Peyronie’s disease BJU Int, 97:625-633
• Singh R, Artaza JN, Taylor WE, Braga M, Yuan X, Gonzalez-Cadavid NF, Bhasin S (2006) Testosterone inhibits adipogenic differentiation in 3T3-L1 cells: nuclear translocation of androgen receptor complex with beta-catenin and T-cell factor 4 may bypass canonical Wnt signaling to down-regulate adipogenic transcription factors. Endocrinology. 2006 Jan;147(1):141-54.
• Vernet D, Magee TR, Qian A, Rajfer J, Gonzalez-Cadavid NF (2006) Long-term continuous incubation with high doses of tadalafil does not up-regulate the levels of phosphodiesterase 5 (pde5) in cultures of human penile smooth muscle cells. J Sex Med 3:84-94; discussion 94-95
• Magee TR, Artaza JN, Ferrini MG, Zuniga FI, Cantini L, Reisz-Porszasz S, Rajfer J, Gonzalez-Cadavid NF (2006). Myostatin shRNA gene therapy increases muscle mass. J Gene Med 8:1171-81
• Kovanecz I, Ferrini MG, Vernet D, Nolazco G, Rajfer J, Gonzalez-Cadavid NF (2006). Pioglitazone prevents corporal veno-occlusive dysfunction (CVOD) in a rat model of type 2 diabetes melittus. BJU Int, 98:116-124
• Ferrini MG, Davila H, Kovanecz I, Sanchez S, Gonzalez-Cadavid NF* Rajfer J* (*: equal contributors) (2006) Long-term continuous treatment with vardenafil prevents fibrosis and preserves smooth muscle content in the rat corpora cavernosa after bilateral cavernosal nerve transection. Urology, 2006 Aug;68(2):429-35.
• Ferrini MG, Kovanecz I, Sanchez S, Vernet D, Davila HH, Rajfer J, Gonzalez-Cadavid NF (2007) ,Long-term continuous treatment with sildenafil ameliorates aging-related erectile dysfunction and the underlying corporal fibrosis. Biol Reprod, 76:915-923
• Artaza JN, Reisz-Porszasz S, Dow JS, Kloner RA, Tsao J, Bhasin S, Gonzalez-Cadavid NF (2007) A lterations in myostatin expression are associated with changes in cardiac left ventricular mass but not ejection fraction in the mouse. J Endocrinol, 194(1):63-76.
• Gonzalez-Cadavid NF , Rajfer J (2007) Experimental models for the study of the cellular and molecular pathophysiology of Peyronie’s disease. In: Current Clinical Urology: Peyronie’s Disease, A Guide to Clinical Management, ed by L.A. Levine, Humana Press, Totowa , NJ , p 19-39
• Magee TR, Kovanecz I, Davila HH, Ferrini MG, Cantini L, Vernet D, Zuniga FI, Rajfer J, Gonzalez-Cadavid NF (2007) Antisense and short hairpin RNA (shRNA) constructs targeting PIN (protein inhibitor of NOS) ameliorate aging-related erectile dysfunction in the rat. J Sex Medic, 4(3):633-43.
• Kovanecz I, Ferrini MG, Davila HH, Rajfer J, Gonzalez-Cadavid NF (2007) Pioglitazone ameliorates penile corpora veno-occlusive dysfunction (CVOD) in the aged rat. BJU Int. 2007 Oct; 100(4):867-74.
• K ovanecz I, Rambhatla A, Ferrini MG, Vernet D, Sanchez S, Rajfer J, Gonzalez -Cadavid NF (2007) Long term sildenafil treatment ameliorates corporal veno-occlusive dysfunction (CVOD) induced by cavernosal nerve resection in rats . Int J Impot Res, 2007, 100(4):867-74.
• Kovanecz I, Rambhatla A, Ferrini MG, Vernet D, Sanchez S, Rajfer J, Gonzalez-Cadavid NF (2008) Chronic daily tadalafil prevents the corporal fibrosis and veno-occlusive dysfunction (CVOD) that occurs following cavernosal nerve resection in the rat. BJU Int 101(2):203-10. 
• Rambhatla A, Kovanecz I, Ferrini M, Gonzalez-Cadavid NF, Rajfer J (2008) Rationale for phosphodiesterase 5 inhibitor use post-radical prostatectomy: experimental and clinical review. Int J Impot Res. 20( 1): 30-4.
• Nolazco G, Kovanecz I, Vernet D, Ferrini M, Gelfand B, Tsao J, Magee T, Rajfer J, Gonzalez-Cadavid NF (2008) Effect of muscle derived stem cells on the restoration of corpora cavernosa smooth muscle and erectile function in the aged rat. BJU Int, 101(9):1156-64
• Artaza JN, Singh R, Ferrini MG, Braga M, Tsao J, Gonzalez-Cadavid NF (2008) Myostatin promotes a fibrotic phenotypic switch in multipotent C3h 10T1/2 cells without affecting their differentiation into myofibroblasts. J Endocrinol 196: 235-49
• Cantini LP, Ferrini MG, Vernet D, Magee TR, Quian A, Gelfand RA, Rajfer J, Gonzalez-Cadavid NF (2008) Pro-fibrotic role of myostatin in Peyronie’s disease. J Sex Med, 5(7):1607-22
• Braga M, Sinha Hikim AP, Datta S, Ferrini MG, Brown D, Kovacheva EL, Gonzalez-Cadavid NF, Sinha-Hikim I (2008) Involvement of oxidative stress and caspase 2-mediated intrinsic pathway signaling in age-related increase in muscle cell apoptosis in mice. Apoptosis. 2008 Jun;13(6):822-32.
• Gonzalez-Cadavid NF , Rajfer J (2009) Experimental models for Peyronie’s disease. Implications for therapy. J Sex Medic, 6(2):303-13
• Ferrini MG, Kovanecz I, Sanchez S, Vernet D, Umeh C, Rajfer J, Gonzalez-Cadavid NF (2009). Fibrosis and loss of smooth muscle in the corpora cavernosa precede corporal veno-occlusive dysfunction (CVOD) induced by experimental cavernosal nerve damage in the rat. J Sex Medic, 6(2):415-28
• Kovanecz I, Nolazco G, Ferrini MG, Toblli, JE, Heydarkhan S, Vernet D, Rajfer J, Gonzalez-Cadavid NF (2008) Early onset of fibrosis within the arterial media in a rat model of type 2 diabetes mellitus exhibiting erectile dysfunction. BJU Int, 2009, 103(10):1396-404
• Gonzalez-Cadavid NF (2009) Mechanisms of penile fibrosis. J Sex Med, 6 Suppl 3:353-62.
• Toblli JE; Ferrini MG; Cao G; Vernet D; Angerosa M; Gonzalez-Cadavid NF (2009) Antifibrotic effects of pioglitazone on the kidney in a rat model of type 2 diabetes mellitus. Nephrol Dial Transpl, Aug;24(8):2384-91..
• Ho MH, Heydarkhan S, Vernet D, Kovanecz I, Ferrini MG, Bhatia NN, Gonzalez-Cadavid NF (2009) Skeletal muscle-derived stem cells seeded on small intestinal submucosal scaffolds stimulate vaginal repair in the rat. Obst Gynecol, Aug;114(2, Part 1):300-309

ACADEMIC ACTIVITIES AND COMMITTEES

 1970 71. Member of the Organizing Committee of the 10th Congress of Latin American Society of Physiological Sciences (ALALC).
 1970 71. Member of the Organizing Committee of the 1st Congress of Pan American Association of Biochemical Societies (PAABS).
 1973 75. Chairman of the Committee on Scientific Research, School of Biology, Central University of Venezuela.
 1978. Member and main writer/editor of the Committee that prepared the text of a bill on the scientific investigator career in Venezuela, Venezuelan National Council of Scientific Research, CONICIT.
 1977 78. Chairman of the Organizing Committee of the 2nd PAABS Congress.
 1976 78. Member of Executive Council of the Venezuela Biochemical Society.
 1978 79. Secretary General of the Pan American Association of Biochemical Societies,
 1979 80. Chairman of the Biology Grants Committee, CONICIT.
 1979 85. Member of the Symposium Committee of the International Union of Biochemistry.
 1981. Advisor to CONICIT on genetic engineering applications to biotechnology
 1981. Advisor to CONICIT on the cooperation agreements with the US National Academy of Sciences.
 1982 84. Vice Chairman of the Committee on Genetic Engineering, CONICIT.
 1974 78. Coordinator of the Research Group on Molecular Biology, School of Biology, Central University of Venezuela.
 1985 87. Member of Technical Council, Center of Cell Biology, Central University of Venezuela.
 1985 86. Member of Post graduate Committee on Cell Biology, Central University of Venezuela.
 1985 89. Member of National Committee on Genetic Engineering and Biotechnology, appointed by the President of Venezuela.
 1985. Scientific Consultant, Lopapa Institute Project.'Institute of Molecular Oncology.'  .
 1985 86. Member of the Committee on Retirements and Pension Plans of the National Council of Universities, and that of the Central University of Venezuela.
 1986. Organizer of the Colombian/Venezuelan Meeting on Binational Biotechnology Projects, Cucuta, Colombia.
 1986. CONICIT representative to the Biotechnology Committee of SELA (Economic System of Latin America).
 1989. Scientific Advisor to the Director of UNESCO on US molecular biology/genetic engineering institutions.
 1993-on. Recombinant DNA Committee, Research and Education Institute, Harbor-UCLA Center
 1998/9. Panel member. First International Consultation on Erectile Dysfunction. World Health Organization/International Union Against Cancer. Amsterdam, Dallas, Paris
 1997. Career investigator (not-activated), National Council of Scientific and Technological Research (CONICET), Buenos Aires, Argentina.
 1998-on. Ad hoc evaluator, National Fund of Science and technology (FONCYT), National Agency of Scientific and Technologic Promotion, Buenos Aires, Argentina
 2001-on. Director, RCMI DNA Repository and Molecular Medicine Core, Charles C. Drew University, Los Angeles, CA
 2001-on. Ad hoc consultant/lecturer: Merck, AMGEN, and several small corporations.
 2002-on. Member of Search Committee for Research Director, Female Sexual Medicine Center,: UCLA School of Medicine, Department of Urology
 2004. Panel member. Second International Consultation on Erectile Dysfunction. World Health Organization/International Union Against Cancer. Paris
 2006. Scientific Advisory Committee, Faculty Senate, Charles R Drew University
 2007. Faculty appointments and promotions committee, Charles R Drew University
 2009. Panel member. Third International Consultation on Erectile Dysfunction. Paris

AD HOC REVIEWER

 Journals: Endocrinology, Nature Medicine, American Journal of Physiology, Biology of Reproduction, Journal of Andrology, Journal of Urology, Urology, Nitric Oxide, Cancer; Journal of Endocrinology, Experimental Gerontology, Asian Journal of Andrology; Journal of Sexual Medicine; Endocrinology; Circulation Research, and others
 NIH: NIDDK, NIH (1995). Center Program Grants on Prostate Growth
 NIDDK, NIH (2001) Diabetes Research and Training Center
 Welcome Trust, England (2002)
  Singapore University, Faculty appointments
 Editorial Board member, Journal of Sexual Medicine

SCIENTIFIC PRESENTATIONS

Invited speaker and presenter in multiple scientific meetings in the USA and overseas, recently mainly for the Americal Urological Association, Endocrine Society, Society of Sexual Medicine, and others. List of 180 titles available on request