Biology and Genetics of Retinal Disease
Principal Investigators:
Michael B. Gorin, MD PhD/ Anna Matynia PhD
Description
Major themes of the laboratory are the identification of disease-causing mutations with whole exome sequencing or transcriptional changes in patient-derived stem cells, neural mechanisms of light-associated pain (photophobia), and mouse models of retinal damage from von Hippel Lindau disease and central retinal artery occlusion.
We use targeted genetic lesioning, transcriptomics, electrophysiology, animal behavior, and other cutting edge techniques in ocular imaging, molecular genetics, and cell biology to better understand the problems faced by our patients so that we can develop new strategies and approaches to treatment and prevention.
- Big Data Bioinformatics and Genetics of Hereditary Retinal Disorders
- Biological Basis and Neural Pathway associated with Light Sensitivity
- Animal models of retinal disease and disorders
Contact Information
Office: DSERC (310) 794-5400
Lab: DSERC 3-123, (301) 825-7519
Email: oph-gorin [email protected]
Location Address
Stein Eye Institute
Doris Stein Eye Research Center
200 Stein Plaza, UCLA
Los Angeles, CA 90095
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