Publications
Selected Publications
Link to other NIH Publications
(*) Indicates Corresponding author
Hu, J., Pauer, G.J., Hagstrom, S.A., Bok, D., DeBenedictis, M.J., Bonilha, V., Hollyfield, J.G., and Radu, R.A.*: Evidence of Complement Dysregulation in Outer Retina of Stargardt Disease Donor Eyes. Redox Biology 2020; 37:101787.
PMID: 33214125 PMCID: PMC7767765 DOI: 10.1016/j.redox.2020.101787
Bonilha, V.L., Bell, B.A., Hu, J., Milliner, C., Pauer, G.J., Hagstrom, S.A., Radu, R.A., and Hollyfield, J.G: Geographic Atrophy: Confocal Scanning Laser Ophthalmoscopy, Histology, and Inflammation in the Region of Expanding Lessions. Invest. Ophthalmol. Vis. Sci. 2020; 5 Jul 1;61(8):15.
PMID: 32658960 PMCID: PMC7425718 DOI: 10.1167/iovs.61.8.15
Fang, Y., Tschulakow, A., Taubitz, T., Illing, B., Biesemeier, A., Julien-Schraermeyer, S., Jiang, Z., Radu, R.A., and Schraermeyer U: Fundus autofluorescence, spectral-domain optical coherence tomography, and histology correlations in Stargardt disease mouse model. FASEB J. 2020 Mar;34(3):3693-3714. Epub 2020 Jan 27.
PMID: 31989709 DOI: 10.1096/fj.201901784RR.
Morshedian, A., Kaylor, J.J., Ng, S.Y., Tsan, A., Frederiksen, R., Xu, T., Yuan, L., Sampath, A.P., Radu, R.A., Fain, G.L., Travis, G.H: Light-driven regeneration of cone visual pigments through a mechanism involving RGR opsin in Müller glial cells. Neuron 2019; 102(6): 1172-1180
PMID: 31056353 PMCID: PMC6586478 DOI: 10.1016/j.neuron.2019.04.004
Lenis, T.L., Hu, J., Ng, S.Y., Jiang, Z., Sarfare, S., Lloyd, M.B., Esposito, N., Samuel, W., Jaworski, C., Bok, D., Finnemann, S., Radeke, M., Redmond, T.M., Travis, G.H., and Radu, R.A.*: Expression of ABCA4 in Retinal Pigment Epithelium and its implications for Stargardt disease. – Proc. Natl. Acad. Sci. USA. 2018; 115(47):E11120-E11127
PMID: 30397118 PMCID: PMC6255167 DOI: 10.1073/pnas.1802519115
McClements, M.E., Barnard, A.R., Singh, M.S., Charbel Issa, P., Jiang, Z., Radu, R.A., and MacLaren, R.E: An AAV dual vector strategy ameliorates the Stargardt phenotype in adult ABCA4-/- mice. Human gene therapy. 2018; 30(5): 590-600
PMID: 30381971 PMCID: PMC6909730 DOI: 10.1089/hum.2018.156
Cook, J.D., Ng, S.Y., Lloyd, M., Eddington, S., Sun H., Nathans, J., Bok, D., Radu, R.A., and Travis, G.H: Peropsin modulates transit of vitamin A from retina to retinal pigment epithelium. J. Biol. Chem. 2018; 292(52):21407-21416
PMID: 29109151 PMCID: PMC5766940 DOI: 10.1074/jbc.M117.812701
Lenis, T.L., Sarfare, S., Jiang, Z., Lloyd, M.B., Bok, D., and Radu, R.A.*: Complement Modulation in the Retinal Pigment Epithelium Rescues Photoreceptor Degeneration in a Mouse Model of Stargardt Disease. Proc. Natl. Acad. Sci. USA. 2017; 114(15):3987-3992 PMID: 28348233 PMCID: PMC5393232 DOI: 10.1073/pnas.1620299114
Kaylor, J.J., Radu, R.A., Bischoff, N., Makshanoff, J., Hu, J., Lloyd, M., Eddington, S., Bianconi, T., Bok, D., Travis, G.H: Diacylglycerol O-acyltransferase type-1 synthesizes retinyl esters in the retina and retinal pigment epithelium. PLoS One. 2015; 10(5):1-14 PMID: 25974161 PMCID: PMC4431840 DOI: 10.1371/journal.pone.0125921
Smit-McBride, Z., Oltjen, S.L., Radu, R.A., Estep, J., Nguyen, A.T., Gong, Q., and Hjelmeland, L.M: Localization of complement factor H gene expression and protein distribution in the mouse outer retina. Molec. Vis. 2015; 21:110-123
PMID: 25684976 PMCID: PMC4323684
Radu, R.A.*, Hu, J., Jiang, Z., and Bok, D: Bisretinoid-mediated Complement Activation on Retinal Pigment Epithelial Cells is Dependent on Complement Factor H Haplotype. J. Biol. Chem. 2014; 289: 9113-9120
PMID: 21464132 PMCID: PMC3099675 DOI: 10.1074/jbc.M110.191866
Charbel Issa, P., Barnard, R.A., Singh, M., Carter, E., Jiang, Z., Radu, R.A., Schraermeyer, U., and MacLaren, R.A: Fundus Autofluorescence in the Abca4-/- Mouse Model of Stargardt Disease - Correlation with Accumulation of A2E, Retinal Function and Histology. Invest. Ophthalmol. Vis. Sci. 2013; 54(8):5602-12
PMID: 23761084 PMCID: PMC3747716 DOI: 10.1167/iovs.13-11688
Mullins, R.F., Kuehn, M.H., Radu, R.A., Enriquez, S., East, J.S., Schindler, E.I., Travis, G.H., Stone, E.M: Autosomal recessive pigmentosa due to ABCA4 mutations: Clinical, pathological and molecular characterization. Invest. Ophthalmol. Vis. Sci. 2012; 53(4):1883-94
PMID: 22395892 PMCID: PMC3995570 DOI: 10.1167/iovs.12-9477
Radu, R.A.*, Hu, J., Yuan, Q., Welch, D.L., Makshanoff, J., Lloyd, M., McMullen, S., Travis, G.H., and Bok, D: Complement System Dysregulation and Inflammation in the Retinal Pigment Epithelium of a Mouse Model for Stargardt Macular Degeneration. J. Biol. Chem. 2011; 286(21): 18593-18601
PMID: 21464132 PMCID: PMC3099675 DOI: 10.1074/jbc.M110.191866
Radu, R.A., Yuan, Q., Hu, J., Peng, J.H., Lloyd, M., Nusinowitz, S. Bok, D., Travis, G.H: Vitamin A Accelerated Accumulation of Lipofuscin Pigments in the RPE of a Mouse Model for ABCA4-mediated Retinal Dystrophies Following Vitamin A Supplementation. Invest. Ophthalmol. Vis. Sci. 2008; 49(9), 3821-3829
PMID: 18515570 PMCID: PMC2851626 DOI: 10.1167/iovs.07-1470
Radu, R.A., Hu, J., Peng, J.H., Bok, D., Mata, N.L., Travis, G.H: Retinal Pigment Epithelium-retinal G Protein Receptor-Opsin Mediates Light-dependent Translocation of all-trans-retinyl Esters for Synthesis of Visual Chromophore in Retinal Pigment Epithelial Cells. J. Biol. Chem. 2008; 283(28), 19730-19730
PMID: 18474598 PMCID: PMC2443657 DOI: 10.1074/jbc.M801288200
Bakall, B., Radu, R.A., Stanton, J.B., Burke, J.M., McKay, B.S., Wadelius, C., Mullins, R.F., Stone, E.M., Travis, G.H., Marmorstein, A.D: Enhanced accumulation of A2E in individuals homozygous or heterozygous for mutations in BEST1 (VMD2). Exp. Eye Res. 2007; 85, 34-43
PMID: 17477921 DOI: 10.1016/j.exer.2007.02.018
Radu, R.A., Han, Y., Bui, T.V., Nusinowitz, S., Bok, D., Lichter, J., Widder, K., Travis, G.H., Mata, N.L. Reductions in Serum Vitamin A Arrest Accumulation of Toxic Retinal Fluorophores: A Potential Therapy for Treatment of Lipofuscin-based Retinal Diseases. Invest. Ophthalmol. Vis. Sci. 2005; 46, 4393-4401.
PMID: 16303925 DOI: 10.1167/iovs.05-0820
Mata, N.L., Ruiz, A., Radu, R.A., Bui, T.V., Travis, G.H. Chicken Retinas Contain a Retinoid Isomerase Activity that Catalyzes the Direct Conversion of all-trans-retinol to 11-cis-retinol. Biochemistry. 2005; 44, 11715-11721 PMID: 16128572.
PMID: 16128572 PMCID: PMC2851629 DOI: 10.1021/bi050942m
Radu, R.A., Mata, N.L., Bagla, A., and Travis, G.H. Light Exposure Stimulates Formation of A2E Oxirane in a Mouse Model of Stargardt's Macular Degeneration. Proc. Natl. Acad. Sci. USA. 2004; 101, 5928-5933; PMCID:PMC395900.
PMID: 15067110 PMCID: PMC395900 DOI: 10.1073/pnas.0308302101
Radu, R.A., Mata, N.L., Nusinowitz, S., Liu, X., Sieving, P.A., and Travis, G.H. Treatment with Isotretinoin Inhibits Lipofuscin Accumulation in a Mouse Model of Recessive Stargardt's Macular Degeneration. Proc. Natl. Acad. Sci. USA. 2003; 100, 4742-4747
PMID: 12671074 PMCID: PMC153626 DOI: 10.1073/pnas.0737855100
Mata, N.L., Radu, R.A., Clemmons, R.S., and Travis, G.H. Isomerization and Oxidation of Vitamin A in Cone-dominant retinas: Evidence for a New Pathway that Mediates Regeneration of Visual Pigments in Daylight. Neuron. 2002; 36, 69-80
PMID: 12367507 PMCID: PMC2851622 DOI: 10.1016/s0896-6273(02)00912-1