Dr. Semlow's lab seeks to understand the origin and repair of pathological chemical DNA damage that drives cancerous transformation and oncogenic inflammation. Dr. Semlow's group uses complementary biochemical and genetic approaches to elucidate the composition and function of DNA repair networks and is developing analytical tools to identify pathological DNA lesions. The insights generated by this work may lead to interventions that sensitize cancer cells to chemotherapy or that limit the accumulation of DNA damage to suppress tumorigenesis.
Donsbach, M., Dürauer, S., Nguyen, K.T., Grünert, F., Yaneva, D., Semlow, D.R., and Stingele, J. (2022) An autorelease mechanism for HMCES-DNA-protein crosslinks. bioRxiv doi: https://doi.org/10.1101/2022.12.18.520715
Semlow, D.R.†, MacKrell, V.A., and Walter, J.C.† (2022) The HMCES DNA-protein cross-link functions as an intermediate in DNA interstrand cross-link repair. Nat. Struct. Mol. Biol. 29:451-462. PMID 35534579 †Co-corresponding author
Semlow, D.R. and Walter, J.C. (2021) Mechanisms of vertebrate DNA interstrand cross-Link repair. Annu. Rev. Biochem. 90: 107-135. PMID: 33882259.