Daniel Semlow

Daniel Semlow, PhD

Assistant Professor of Biochemistry, Division of Chemistry and Chemical Engineering, Caltech



Institutional Affiliation




Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, 2020


PhD, The University of Chicago, Chicago, IL, 2015
BS, University of Illinois at Urbana-Champaign, Champaign, IL, 2005

Scientific Interests

Dr. Semlow's lab seeks to understand the origin and repair of pathological chemical DNA damage that drives cancerous transformation and oncogenic inflammation. Dr. Semlow's group uses complementary biochemical and genetic approaches to elucidate the composition and function of DNA repair networks and is developing analytical tools to identify pathological DNA lesions. The insights generated by this work may lead to interventions that sensitize cancer cells to chemotherapy or that limit the accumulation of DNA damage to suppress tumorigenesis.

Highlighted Publications

Donsbach, M., Dürauer, S., Nguyen, K.T., Grünert, F., Yaneva, D., Semlow, D.R., and Stingele, J. (2022) An autorelease mechanism for HMCES-DNA-protein crosslinks. bioRxiv doi: https://doi.org/10.1101/2022.12.18.520715

Semlow, D.R.†, MacKrell, V.A., and Walter, J.C.† (2022) The HMCES DNA-protein cross-link functions as an intermediate in DNA interstrand cross-link repair. Nat. Struct. Mol. Biol. 29:451-462. PMID 35534579 †Co-corresponding author

Semlow, D.R. and Walter, J.C. (2021) Mechanisms of vertebrate DNA interstrand cross-Link repair. Annu. Rev. Biochem. 90: 107-135. PMID: 33882259.