Most of Dr. Dorthe Schaue's research focuses on tumor-specific immune responses following radiation therapy in mice and men. The idea is that radiation appears to shape the immune balance. Although often considered to be immunosuppressive, radiation therapy can in fact drive anti-tumor immune reactivity in a dose-dependent fashion, acting either directly or through danger signaling pathways. Ultimately, Schaue's goal is to tune the radiation response to immunotherapeutic approaches in order to maximize the interaction and improve outcome.
Schaue D. A Century of Radiation Therapy and Adaptive Immunity. Front Immunol. 2017 Apr 11;8:431. doi: 10.3389/fimmu.2017.00431. eCollection 2017. Review.
Ratikan JA, Micewicz ED, Xie MW, Schaue D. Radiation takes its Toll. Cancer Lett. 2015 Nov 28;368(2):238-45. doi: 10.1016/j.canlet.2015.03.031. Epub 2015 Mar 25. Review.
Ratikan JA, Sayre JW, Schaue D. Chloroquine engages the immune system to eradicate irradiated breast tumors in mice. Int J Radiat Oncol Biol Phys. 2013 Nov 15;87(4):761-8. doi: 10.1016/j.ijrobp.2013.07.024.
Schaue D, Ratikan JA, Iwamoto KS, McBride WH. Maximizing tumor immunity with fractionated radiation. Int J Radiat Oncol Biol Phys. 2012 Jul 15;83(4):1306-10. doi: 10.1016/j.ijrobp.2011.09.049. Epub 2011 Dec 28.
Kachikwu EL, Iwamoto KS, Liao YP, DeMarco JJ, Agazaryan N, Economou JS, McBride WH, Schaue D. Radiation enhances regulatory T cell representation. Int J Radiat Oncol Biol Phys. 2011 Nov 15;81(4):1128-35. doi: 10.1016/j.ijrobp.2010.09.034. Epub 2010 Nov 17.