Dr. Elizabeth Tarling is interested in mechanisms that control cellular and whole-body lipid homeostasis in health and disease. Dysregulation of cellular and/or plasma lipid levels results in many different metabolic disease, including diabetes, cardiovascular disease (CVD) and cancer. Tarling's lab has focused on investigating the role of the ATP binding cassette transporter ABCG1 in lipid metabolism, inflammation, atherosclerosis and innate immunty. Tarling is currently studying the role of ABCG1 in pulmonary lipid homeostasis, immunity and human disease.
York AG, Williams KJ, Argus JP, Zhou QD, Brar G, Vergnes L, Gray EE, Zhen A, Wu NC, Yamada DH, Cunningham CR, Tarling EJ, Wilks MQ, Casero D, Gray DH, Yu AK, Wang ES, Brooks DG, Sun R, Kitchen SG, Wu TT, Reue K, Stetson DB, Bensinger SJ. Limiting Cholesterol Biosynthetic Flux Spontaneously Engages Type I IFN Signaling. Cell. 2015 Dec 17;163(7):1716-29. doi: 10.1016/j.cell.2015.11.045.
Baldan A, Gonen A, Choung C, Que X, Marquart TJ, Hernandez I, Bjorkhem I, Ford DA, Witztum JL, Tarling EJ. ABCG1 is required for pulmonary B-1 B cell and natural antibody homeostasis. J Immunol. 2014 Dec 1;193(11):5637-48. doi: 10.4049/jimmunol.1400606.
Tarling EJ, Edwards PA. ATP binding cassette transporter G1 (ABCG1) is an intracellular sterol transporter. Proc Natl Acad Sci U S A. 2011 Dec 6;108(49):19719-24. doi: 10.1073/pnas.1113021108.