Dr. Ellen Sletten's lab leverages the unique properties of fluorinated materials to develop new diagnostic and therapeutic nanotechnologies. They exploit the orthogonality of the fluorous phase to prepare multifunctional nanomaterials, which can be personalized and tailored to different patients and cancers. Separate efforts within the lab involve the creation of contrast agents for the shortwave infrared region of the electromagnetic spectrum where the penetration of light through tissue is enhanced. Imaging in this region offers opportunities for low-cost, safe, rapid cancer diagnostics as well as advancements in image-guided tumor resection.
Day RA, Estabrook DA, Logan JK, Sletten EM. Fluorous photosensitizers enhance photodynamic therapy with perfluorocarbon nanoemulsions. Chem Commun (Camb). 2017 Dec 5;53(97):13043-13046. doi: 10.1039/c7cc07038a.
Cosco ED, Caram JR, Bruns OT, Franke D, Day RA, Farr EP, Bawendi MG, Sletten EM. Flavylium Polymethine Fluorophores for Near- and Shortwave Infrared Imaging. Angew Chem Int Ed Engl. 2017 Oct 9;56(42):13126-13129. doi: 10.1002/anie.201706974. Epub 2017 Sep 14.