Evan Abt, PhD

Evan Abt, PhD

Assistant Professor, Department of Molecular and Medical Pharmacology





Postdoctoral Training in Tumor Immunology and Nucleotide Metabolism, University of California, Los Angeles, CA, 2023


PhD, University of California, Los Angeles, CA, 2020
BSc, University of California, Santa Cruz, CA, 2012

Contact Information

Scientific Interests

Dr. Abt's research focus has been to address critical gaps in knowledge regarding the functional links between immune cell activation and nucleotide metabolism and to apply this new insight towards the development of immunotherapies for cancer patients.

Highlighted Publications

Abt ER, Rashid K, Le TM, Li S, Lee HR, Lok V, Li L, Creech AL, Labora AN, Mandl HK, Lam AK, Cho A, Rezek V, Wu N, Abril-Rodriguez G, Rosser EW, Mittelman SD, Hugo W, Mehrling T, Bantia S, Ribas A, Donahue TR, Crooks GM, Wu TT, Radu CG. Purine nucleoside phosphorylase enables dual metabolic checkpoints that prevent T cell immunodeficiency and TLR7-dependent autoimmunity. J Clin Invest. 2022; PubMed PMID: 35653193.

Abt ER, Le TM, Dann AM, Capri JR, Poddar S, Lok V, Li L, Liang K, Creech AL, Rashid K, Kim W, Wu N, Cui J, Cho A, Lee HR, Rosser EW, Link JM, Czernin J, Wu TT, Damoiseaux R, Dawson DW, Donahue TR, Radu CG. Reprogramming of nucleotide metabolism by interferon confers dependence on the replication stress response pathway in pancreatic cancer cells. Cell Rep. 2022; 38(2). PubMed PMID: 35021095.

Abt ER*, Liang K*, Le TM, Cho A, Dann AM, Cui J, Li L, Rashid K, Creech AL, Wei L, Ghukasyan R, Rosser EW, Wu N, Carlucci G, Czernin J, Donahue TR, Radu CG. STING-driven interferon signaling triggers metabolic alterations in pancreas cancer cells visualized by [^18^F]FLT PET imaging. Proc Natl Acad Sci U S A. 2021; 118(36). PubMed PMID: 34480004. PMCID: PMC8433573.

Abt ER, Rosser EW, Durst MA, Lok V, Poddar S, Le TM, Cho A, Kim W, Wei L, Song J, Capri JR, Xu S, Wu N, Slavik R, Jung ME, Damoiseaux R, Czernin J, Donahue TR, Lavie A, Radu CG. Metabolic Modifier Screen Reveals Secondary Targets of Protein Kinase Inhibitors within Nucleotide Metabolism. Cell Chem Biol. 2020; 27(2). PubMed PMID: 31734178. PMCID: PMC7035983.

Le TM, Lee HR, Abt ER, Rashid K, Creech AL, Liang K, Cui J, Cho A, Wei L, Labora A, Chan C, Sanchez E, Kriti K, Karin D, Li L, Wu N, Mona C, Carlucci G, Hugo W, Wu TT, Donahue TR, Czernin J, Radu CG. ^18^F-FDG PET visualizes systemic STING agonist-induced lymphocyte activation in preclinical models. J Nucl Med. 2022; PubMed PMID: 35738905.