Feng Li, PhD

Feng Li, PhD

Adjunct Assistant Professor, School of Dentistry, Division of Oral and Systemic Health Sciences





Biochemistry and Molecular Biology, Howard Hughes Medical Institute, UCLA, Los Angeles, CA, 2005
Biochemistry and Molecular Biology, University of California, Los Angeles, CA, 2010


MS, Hunan Normal University, Changsha, China, 1999
BS, Hunan Normal University, Changsha, China, 1996
PhD, Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, China, 2003

Contact Information

Scientific Interests

Dr. Li's research interest centers on leveraging liquid biopsy to unravel the complex molecular signatures of cancer, with a particular emphasis on understanding tumor heterogeneity, tumor microenvironment dynamics, and immune evasion mechanisms. By interrogating circulating tumor DNA (ctDNA), extracelluar RNA (exRNA) and extracellular vesicles(EVs), Dr. Li aims to decipher the multi-omics landscapes of tumors across different stages of disease progression and in response to treatment interventions. His research endeavors to uncover novel biomarkers for cancer early detection, therapeutic resistance and recurrence, ultimately informing the development of novel liquid biopsy-based assays to improve patient outcomes and advance the paradigm of personalized cancer care.

Highlighted Publications

Cheng J, Swarup N, Li F, Kordi M, Lin CC, Yang SC, Huang WL, Aziz M, Kim Y, Chia D, Yeh YM, Wei F, Zheng D, Zhang L, Pellegrini M, Su WC, Wong DTW. Distinct Features of Plasma Ultrashort Single-Stranded Cell-Free DNA as Biomarkers for Lung Cancer Detection. Clinical chemistry. 2023;69(11):1270-82.

Salfer B, Li F, Wong DTW, Zhang L. Urinary Cell-Free DNA in Liquid Biopsy and Cancer Management. Clinical chemistry. 2022;68(12):1493-501.

Li F, Wei F, Grogan TR, Elashoff DE, Vu D, Vigerust DJ, Gupta R, Wong DTW. Proficiency Testing of Epidermal Growth Factor Receptor Mutations Detection in Saliva Using Spectrum Saliva Collector (SDNA-1000) and Preservative Solution Detected by Electric Field-Induced Release and Measurement. Biopreserv Biobank. 2022;20(5):461-4. PMCID:PMC9603249.

Li F, Wei F, Huang WL, Lin CC, Li L, Shen MM, Yan Q, Liao W, Chia D, Tu M, Tang JH, Feng Z, Kim Y, Su WC, Wong DTW. Ultra-Short Circulating Tumor DNA (usctDNA) in Plasma and Saliva of Non-Small Cell Lung Cancer (NSCLC) Patients. Cancers (Basel). 2020;12(8).

Wang Z, Li F, Rufo J, Chen C, Yang S, Li L, Zhang J, Cheng J, Kim Y, Wu M, Abemayor E, Tu M, Chia D, Spruce R, Batis N, Mehanna H, Wong DTW, Huang TJ. Acoustofluidic Salivary Exosome Isolation: A Liquid Biopsy Compatible Approach for Human Papillomavirus-Associated Oropharyngeal Cancer Detection. J Mol Diagn. 2020;22(1):50-9. PMCID:PMC6943372.