Dr. Guido Eibl has been interested in pancreatic research since 1996. Initially, he studied the pathophysiology and experimental therapeutics in acute pancreatitis. After joining UCLA in 2000 Eibl directed his research towards pancreatic cancer. For more than 15 years now, his main research interest continues to be the study of pancreatic cancer, in particular the role of inflammation in cancer development and progression. He initially studied the role of eicosanoids and cyclooxygenases as targets for pancreatic cancer therapy and from these studies Eibl became interested in the anti-inflammatory role of fish oil and omega-3 polyunsaturated fatty acids for pancreatic cancer prevention and therapy. He is also involved in projects studying the efficacy of natural compounds for pancreatic cancer prevention and therapy.
For the past five years Eibl has been interested in the link between obesity and cancer development. He found that a diet high in fats and calories leads to obesity in mice with insulin resistance similar to humans and accelerates pancreatic cancer development in a genetically-engineered mouse model of pancreatic cancer. He currently is investigating interventional strategies to reduce obesity-associated adipose tissue inflammation and pancreatic cancer incidence. These studies are now funded by a Program Project Grant.
Ming M, Sinnett-Smith J, Wang J, Soares HP, Young SH, Eibl G, Rozengurt E. Dose-Dependent AMPK-Dependent and Independent Mechanisms of Berberine and Metformin Inhibition of mTORC1, ERK, DNA Synthesis and Proliferation in Pancreatic Cancer Cells. PLoS One. 2014 Dec 10;9(12):e114573. doi: 10.1371/journal.pone.0114573. eCollection 2014.
Lau C, Kim Y, Chia D, Spielmann N, Eibl G, Elashoff D, Wei F, Lin YL, Moro A, Grogan T, Chiang S, Feinstein E, Schafer C, Farrell J, Wong DT. Role of pancreatic cancer-derived exosomes in salivary biomarker development. J Biol Chem. 2013 Sep 13;288(37):26888-97. doi: 10.1074/jbc.M113.452458. Epub 2013 Jul 23.
Dawson DW, Hertzer K, Moro A, Donald G, Chang HH, Go VL, Pandol SJ, Lugea A, Gukovskaya AS, Li G, Hines OJ, Rozengurt E, Eibl G. High-fat, high-calorie diet promotes early pancreatic neoplasia in the conditional KrasG12D mouse model. Cancer Prev Res (Phila). 2013 Oct;6(10):1064-73. doi: 10.1158/1940-6207.CAPR-13-0065. Epub 2013 Aug 13.
Takahashi H, Chen MC, Pham H, Angst E, King JC, Park J, Brovman EY, Ishiguro H, Harris DM, Reber HA, Hines OJ, Gukovskaya AS, Go VL, Eibl G. Baicalein, a component of Scutellaria baicalensis, induces apoptosis by Mcl-1 down-regulation in human pancreatic cancer cells. Biochim Biophys Acta. 2011 Aug;1813(8):1465-74. Epub 2011 May 10
Funahashi H, Satake M, Dawson D, Huynh NA, Reber HA, Hines OJ, Eibl G. Delayed progression of pancreatic intraepithelial neoplasia in a conditional Kras(G12D) mouse model by a selective cyclooxygenase-2 inhibitor. Cancer Res. 2007 Aug 1;67(15):7068-71. Epub 2007 Jul 24