Heather Maynard, PhD, MS
Dr. Heather Maynard's laboratory integrates synthetic polymers with naturally-derived biomolecules to treat and detect cancer. The group develops novel synthetic methods to make important classes of cancer therapeutics including protein- or siRNA-polymer conjugates. They also focus on delivery of small molecule cancer drugs from nanocapsules. In addition, they develop diagnostics for the early detection of cancer. Maynard's approach involves many disciplines including polymer chemistry, biochemistry, and nanofabrication.
Pelegri-O'Day EM, Paluck SJ, Maynard HD. Substituted Polyesters by Thiol-Ene Modification: Rapid Diversification for Therapeutic Protein Stabilization. J Am Chem Soc. 2017 Jan 25;139(3):1145-1154. doi: 10.1021/jacs.6b10776. Epub 2017 Jan 12.
Lau UY, Saxer SS, Lee J, Bat E, Maynard HD. Direct Write Protein Patterns for Multiplexed Cytokine Detection from Live Cells Using Electron Beam Lithography. ACS Nano. 2016 Jan 26;10(1):723-9. doi: 10.1021/acsnano.5b05781. Epub 2015 Dec 21.
Lorenzo MM, Decker CG, Kahveci MU, Paluck SJ, Maynard HD. Homodimeric Protein-Polymer Conjugates via the Tetrazine-trans-Cyclooctene Ligation. Macromolecules. 2016 Jan 12;49(1):30-37. Epub 2015 Dec 23.
Boehnke N, Cam C, Bat E, Segura T, Maynard HD. Imine Hydrogels with Tunable Degradability for Tissue Engineering. Biomacromolecules. 2015 Jul 13;16(7):2101-8. doi: 10.1021/acs.biomac.5b00519. Epub 2015 Jul 1.
Bat E, Lee J, Lau UY, Maynard HD. Trehalose glycopolymer resists allow direct writing of protein patterns by electron-beam lithography. Nat Commun. 2015 Mar 20;6:6654. doi: 10.1038/ncomms7654.