Dr. Holden Wu is interested in developing rapid and robust quantitative magnetic resonance imaging (MRI) techniques for improving diagnosis and treatment in oncologic and cardiovascular applications. His lab focuses on technical developments in MRI pulse sequence design, accelerated data acquisition, new image reconstruction algorithms and quantitative data analysis. These advanced techniques are used to improve early detection of disease, characterize the disease state, facilitate treatment planning, guide interventions, assess treatment efficacy and perform monitoring.
Deng T, Zhang L, Wu HH, Zink JI. A nanoparticle enabled focused ultrasound-stimulated magnetic resonance imaging spotlight. Chem Commun (Camb). 2019 Aug 22;55(69):10261-10264. doi: 10.1039/c9cc03701b.
Armstrong T, Ly KV, Murthy S, Ghahremani S, Kim GHJ, Calkins KL, Wu HH. Free-breathing quantification of hepatic fat in healthy children and children with nonalcoholic fatty liver disease using a multi-echo 3-D stack-of-radial MRI technique. Pediatr Radiol. 2018 Jul;48(7):941-953. doi: 10.1007/s00247-018-4127-7. Epub 2018 May 4.
Wu HH, Priester A, Khoshnoodi P, Zhang Z, Shakeri S, Afshari Mirak S, Asvadi NH, Ahuja P, Sung K, Natarajan S, Sisk A, Reiter R, Raman S, Enzmann D. A system using patient-specific 3D-printed molds to spatially align in vivo MRI with ex vivo MRI and whole-mount histopathology for prostate cancer research. J Magn Reson Imaging. 2019 Jan;49(1):270-279. doi: 10.1002/jmri.26189. Epub 2018 Aug 2.
Armstrong T, Dregely I, Stemmer A, Han F, Natsuaki Y, Sung K, Wu HH. Free-breathing liver fat quantification using a multiecho 3D stack-of-radial technique. Magn Reson Med. 2018 Jan;79(1):370-382. doi: 10.1002/mrm.26693. Epub 2017 Apr 16.
Dregely I, Margolis DA, Sung K, Zhou Z, Rangwala N, Raman SS, Wu HH. Rapid quantitative T2 mapping of the prostate using three-dimensional dual echo steady state MRI at 3T. Magn Reson Med. 2016 Dec;76(6):1720-1729. doi: 10.1002/mrm.26053. Epub 2016 Jan 13.