Dr. Linda Cai's group is interested in nitric oxide and reactive oxygen species signaling in cultured cells, models of cardiovascular diseases such as hypertension and atherosclerosis, angiogenesis and cardiovascular complications of cancer drugs.
Youn JY, Nguyen A, Cai H. Inhibition of XO or NOX attenuates diethylstilbestrol-induced endothelial nitric oxide deficiency without affecting its effects on LNCaP cell invasion and apoptosis. Clin Sci (Lond). 2012 Oct;123(8):509-18. doi: 10.1042/CS20110407.
Nguyen A, Cai H. Netrin-1 induces angiogenesis via a DCC-dependent ERK1/2-eNOS feed-forward mechanism. Proc Natl Acad Sci U S A. 2006 Apr 25;103(17):6530-5. Epub 2006 Apr 12.
Chalupsky K, Cai H. Endothelial dihydrofolate reductase: critical for nitric oxide bioavailability and role in angiotensin II uncoupling of endothelial nitric oxide synthase. Proc Natl Acad Sci U S A. 2005 Jun 21;102(25):9056-61. Epub 2005 Jun 7.
Cai H. NAD(P)H oxidase-dependent self-propagation of hydrogen peroxide and vascular disease. Circ Res. 2005 Apr 29;96(8):818-22.
Cai H. Hydrogen peroxide regulation of endothelial function: origins, mechanisms, and consequences. Cardiovasc Res. 2005 Oct 1;68(1):26-36.