Hua Linda Cai, MD, PhD

Hua Linda Cai, MD, PhD

Professor, Department of Anesthesiology, Department of Medicine



Scientific Interests

Dr. Linda Cai's group is interested in nitric oxide and reactive oxygen species signaling in cultured cells, models of cardiovascular diseases such as hypertension and atherosclerosis, angiogenesis and cardiovascular complications of cancer drugs.

Highlighted Publications

Youn JY, Middlekauff HR, Reudiseuli I, Huang K, Cai H. Endothelial damage in young adult e-cigarette users. Redox Biol. 2023 Mar;62:102688.  [Abstract & Full Text]

Zhang Y, Wang X, Liu Y, Zhou J, Gong H, Li XK, Lv SJ, Chen XF, Ren SC, Zhang H, Yan B, Dai Y, Cai H, Tang X, Chen HZ. SIRT2 deficiency amplifies a cytoplasm-mitochondrial signal to aggravates aging-induced vascular remodeling in humans and mice. European Heart Journal. 2023;44,2746-2759.  [Abstract & Full Text]

Cabrera JT, Si R, Tsuji-Hosokawa A, Cai H, Yuan JXJ, Dillmann WH, Makino A. Restoration of coronary microvascular function by OGA overexpression in a high-fat diet with low dose streptozotocin-induced type 2 diabetic mice. Diabetes and Vascular Disease Research. 2023 May-June;1-13.  [Abstract & Full Text]

Fischer MA, Chapski DJ, Soehalim E, Montoya DJ, Grogan T, Pellegrini M, Cai H, Shemin RJ, Vondriska TM. Longitudinal profiling in patients undergoing cardiac surgery reveals postoperative changes in DNA methylation. Clin. Epigenetics. 2022 Dec 30;14(1):195. doi: 10.1186/s13148-022-01414-4.  [Abstract & Full Text]

Huang K, Wu Y, Zhang Y, Youn JY, Cai H. Combination of folic acid with nifedipine is completely effective in attenuating aortic aneurysm formation as a novel oral medication. Redox Biol. 2022 Dec;58:102521.  [Abstract & Full Text]