Israa Laklouk, MD

Israa Laklouk, MD

Assistant Professor, Department of Pathology





Head and Neck Pathology, Massachusetts General Hospital, Boston, MA, 2020
Surgical Pathology, University of California, San Francisco, 2021


University of Tripoli School of Medicine, Tripoli, Libya, 2008


MD, University of Tripoli School of Medicine, Tripoli, Libya, 2007


Anatomic Pathology, Tripoli Medical Center, Tripoli, Libya, 2011
Anatomic and Clinical Pathology, Boston University Medical Center, Boston, MA, 2019

Board Certifications

Advanced Training in Clinical Research, University of California, San Francisco, 2015
Pathology-Anatomic/Pathology-Clinical, American Board of Pathology, 2020

Contact Information

Scientific Interests

Dr. Laklouk is interested in studying the variability of the immune microenvironment and its prognostic potential in surgically removed non-oropharyngeal squamous cell carcinoma of the head and neck. Additionally, she'll investigate the significance of intratumoral tertiary lymphoid structures (TLSs), which have shown controversial prognostic value in other cancers but are poorly understood in this context.

Highlighted Publications

Bishop JA, Nakaguro M, Whaley RD, Ogura K, Imai H, Laklouk Israa, Faquin WC, Sadow PM, Gagan J, Nagao T. Oncocytic intraductal carcinoma of salivary glands: a distinct variant with TRIM33-RET fusions and BRAF V600E mutations. Histopathology. 2021 Sep;79(3):338-346. Doi: 10.1111/his.14296. Epub 2021 Mar 31. PMID: 33135196; PMCID: PMC8315294

Fisch, Adam S., Israa Laklouk, Masato Nakaguro, Vânia Nosé, Lori J. Wirth, Daniel G. Deschler, William C. Faquin, Dora Dias-Santagata, and Peter M. Sadow. "Intraductal carcinoma of the salivary gland with NCOA4- RET: expanding the morphologic spectrum and an algorithmic diagnostic approach." Human pathology 114 (2021): 74-89. Doi: 10.1016/j.humpath.2021.05.004. Epub 2021 May 12. PMID: 33991527 * These authors contributed equally to this article

van der Wal D, Jhun I, Laklouk Israa, Nirschl J, Richer L, Rojansky R, Theparee T, Wheeler J, Sander J, Feng F, Mohamad O, Savarese S, Socher R, Esteva A. Biological data annotation via a human-augmenting AI-based labeling system. NPJ Digit Med. 2021 Oct 7;4(1):145. Doi: 10.1038/s41746-021-00520-6. PMID: 34620993; PMCID: PMC8497580

Shapiro, Daniel D., Brendan Dolan, Israa A. Laklouk, Sahar Rassi, Taja Lozar, Hamid Emamekhoo, Andrew L. Wentland, Meghan G. Lubner, and Edwin Jason Abel. "Understanding the Tumor Immune Microenvironment in Renal Cell Carcinoma." Cancers 15, no. 9 (2023): 2500. Doi: 10.3390/cancers15092500. PMID: 37173966; PMCID: PMC10177515

Lozar, Taja, Israa Laklouk, Athena E. Golfinos, Niki Gavrielatou, Jin Xu, Christopher Flynn, Aysenur Keske et al. "Stress Keratin 17 Is a Predictive Biomarker Inversely Associated with Response to Immune Check-Point Blockade in Head and Neck Squamous Cell Carcinomas and Beyond." Cancers 15, no. 19 (2023): 4905. Doi: 10.3390/cancers15194905. PMID: 37835599; PMCID: PMC10571921.