James Gimzewski

James K. Gimzewski, PhD, DSc hc

Distinguished Professor, Department of Chemistry and Biochemistry
Faculty Director, California NanoSystems Institute (CNSI) Nano and Pico Characterization Core Facility
Scientific Director, UCLA Art/Sci Center
Principal Investigator and Satellites Co-Director, World Premier International (WPI) Center for Materials NanoArchitectonics (MANA), NIMS, Japan



Contact Information

Scientific Interests

Dr. James Gimzewski's current research activities include correlation of nanomechanics of cells and single molecule force spectroscropy of cancer cells using atomic force microscopy/ spectroscopy STED, SEM and optical interformerty. He has been recently active in the area of exosomes relating to brain cancer and developing fine needle elastography of thyroid tissue. He also studies RNA single molecule profiles with AFM and neuronal protein binding with actin.

Highlighted Publications

Shimizu H, Schredelseker J, Huang J, Lu K, Naghdi S, Lu F, Franklin S, Fiji HD, Wang K, Zhu H, Tian C, Lin B, Nakano H, Ehrlich A, Nakai J, Stieg AZ, Gimzewski JK, Nakano A, Goldhaber JI, Vondriska TM, Hajnoczky G, Kwon O, Chen JN. Mitochondrial Ca(2+) uptake by the voltage-dependent anion channel 2 regulates cardiac rhythmicity. Elife. 2015 Jan 15;4. doi: 10.7554/eLife.04801.

Wickramaratne D, Wilkinson P, Rao J, Ragavendra N, Sharma S, Gimzewski JK. Fine Needle Elastography (FNE) device for biomechanically determining local variations of tissue mechanical properties. J Biomech. 2015 Jan 2;48(1):81-8. doi: 10.1016/j.jbiomech.2014.10.038. Epub 2014 Nov 14.

Sharma S, Santiskulvong C, Rao J, Gimzewski JK, Dorigo O. The role of Rho GTPase in cell stiffness and cisplatin resistance in ovarian cancer cells. Integr Biol (Camb). 2014 Jun;6(6):611-7. doi: 10.1039/c3ib40246k.

Sharma S, Zhu H, Grintsevich EE, Reisler E, Gimzewski JK. Correlative nanoscale imaging of actin filaments and their complexes. Nanoscale. 2013 Jul 7;5(13):5692-702. doi: 10.1039/c3nr01039b. Epub 2013 Jun 3.

Cross SE, Jin YS, Rao J, Gimzewski JK. Nanomechanical analysis of cells from cancer patients. Nat Nanotechnol. 2007 Dec;2(12):780-3. doi: 10.1038/nnano.2007.388. Epub 2007 Dec 2.