Dr. Link’s primary activities over the last decade have been to generate the resources, infrastructure, and patient-derived models for translational research in pancreatic adenocarcinoma. His specific research interest is studying the unique tumor immunity and primary tumor properties that allow some patients with PDAC to survive many years with indolent metastatic disease. Dr. Link’s background is in immunology and MYC-related oncogenisis.
The replication stress response kinase ATR is an interferon signaling driven co-dependency in pancreas cancer cells. Evan R. Abt, Thuc M. Le1, Amanda M. Dann, Joseph R. Capri, Soumya Poddar, Vincent Lok, Luyi Li, Keke Liang, Khalid Rashid, Amanda L. Creech, Woosuk Kim, Nanping Wu, Jing Cui, Arthur Cho, Hailey Rose Lee, Ethan W. Rosser, Jason M. Link, Johannes Czernin, Ting-Ting Wu, Robert Damoiseaux, David W. Dawson, Timothy R. Donahue, and Caius G. Radu. 2022. Cell Reports.
Ryan M. Mulqueen, Dmitry Pokholok, Brendan L. O'Connell, Casey A. Thornton, Fan Zhang, Brian J. O’Roak, Jason Link, Galip Gurkan Yardimci, Rosalie C. Sears, Frank J. Steemers, Andrew C. Adey. 2021. High-content single-cell combinatorial indexing. Nature Biotechnology
Jason M. Link, Shannon M. Liudahl, Courtney B. Betts, Shamilene Sivagnanam, Kenna R. Leis, Mary McDonnell, Carl R. Pelz, Brett Johnson, Kelly J. Hamman, Dove Keith, Jone E. Sampson, Terry K. Morgan, Charles D. Lopez, Lisa M. Coussens, and Rosalie C. Sears 2021 Tumor Infiltrating Leukocyte Phenotypes Distinguish Outcomes in Related Patients with Pancreatic Adenocarcinoma. JCO Precision Oncology
Shannon M. Liudahl, Courtney B. Betts, Shamilene Sivagnanam, Vicente Morales-Oyarvide, Annacarolina da Silva, Chen Yuan, Samuel Hwang , Alison Grossblatt-Wait, Kenna R. Leis , William Larson, Meghan B. Lavoie, Padraic Robinson, Andressa Dias Costa, Sara A. Väyrynen , Thomas E. Clancy, Douglas A. Rubinson, Jason Link, Dove Keith, Wesley Horton, Margaret A. Tempero, Robert H. Vonderheide, Elizabeth M. Jaffee, Brett Sheppard, Jeremy Goecks, Rosalie C. Sears, Byung S. Park, Motomi Mori, Jonathan Nowak, Brian M. Wolpin, and Lisa M. Coussens. 2021. Leukocyte Heterogeneity in Pancreatic Ductal Adenocarcinoma: Phenotypic and Spatial Features Associated with Clinical Outcome. Cancer Discovery.
Sohinee Bhattacharyya, Chet Oon, Aayush Kothari, Wesley Horton, Jason Link, Rosalie Sears, and Mara Sherman. 2020 Acidic fibroblast growth factor underlies microenvironmental regulation of MYC in pancreatic cancer. J Exp Med 217(8) e20191805