Jonathan Jacobs, MD, PhD

Jonathan Jacobs, MD, PhD

Assistant Professor in Residence, Department of Medicine, Digestive Diseases



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Scientific Interests

Dr. Jonathan Jacobs studies how intestinal microbes interact with intestinal cells and the immune system to promote diseases including inflammatory bowel disease, obesity and colon cancer. This involves a translational approach that combines detailed characterization of the microbiome of human subjects by 16S ribosomal RNA sequencing, metagenomics and metabolomics and modeling of the effect of disease-associated human microbial communities in mice colonized with human microbiota. The Jacobs Laboratory also operates the UCLA Microbiome Core to provide a comprehensive suite of microbiome-related services to members of the UCLA scientific community. Currently, the Jacobs Laboratory is studying the intestinal microbiome of colon cancer patients before and after curative resection/chemotherapy and is also investigating the use of microbial biomarkers for colon cancer screening.