Julian A. Martinez-Agosto

Julian A. Martinez-Agosto, MD, PhD, FACMG

Associate Professor, Department of Human Genetics and Department of Pediatrics
Associate Director, UCLA Preconception Clinic




Clinical Genetics, Pediatrics

Institutional Affiliation

Ronald Reagan UCLA Medical Center
UCLA Medical Center, Santa Monica
Resnick Neuropsychiatric Hospital at UCLA



Medical Genetics, Cedars-Sinai Medical Center, 2003 - 2005


Pediatrics, UCLA School of Medicine, 2000 - 2001


MD, PhD, Yale School of Medicine, 2000


Pediatrics, UCLA School of Medicine, 2001 - 2003

Board Certifications

Clinical Genetics (M.D.), American Board of Medical Genetics, 2005
Pediatrics, American Board of Pediatrics, 2004

Scientific Interests

Dr. Julian Martinez is interested in understanding the common signal transduction pathways across cancer predisposition genetic syndromes, in particular Noonan, Costello, Craniofaciocutaneous, Neurofibromatosis and overgrowth syndromes (Sotos, Beckwith-Wiedemann, Weaver, Simpson-Golabi-Behmel) and their associated malignancies: neuroblastoma, sarcomas, and leukemias.

To this end, Dr. Martinez utilizes Drosophila melanogaster as a model organism in which to study the cellular and genetic mechanisms that lead to oncogenesis due to the signal transduction pathways disrupted in these syndromes.

Highlighted Publications

Tieu KS, Tieu RS, Martinez-Agosto JA, Sehl ME. Stem cell niche dynamics: from homeostasis to carcinogenesis. Stem Cells Int. 2012 Feb 9;2012:367567.

Mondal BC, Mukherjee T, Mandal L, Evans CJ, Sinenko SA, Martinez-Agosto JA, Banerjee U. Interaction between differentiating cell- and niche-derived signals in hematopoietic progenitor maintenance. Cell. 2011 Dec 23;147(7):1589-600.

Chang VY, Quintero-Rivera F, Baldwin EE, Woo K, Martinez-Agosto JA, Fu C, Gomperts BN. B-acute lymphoblastic leukemia and cystinuria in a patient with duplication 22q11.21 detected by chromosomal microarray analysis. Pediatr Blood Cancer. 2011 Mar;56(3):470-3. Epub 2010 Nov 28

Sinenko SA, Mandal L, Martinez-Agosto JA, Banerjee U. Dual role of wingless signaling in stem-like hematopoietic precursor maintenance in Drosophila. Dev Cell. 2009 May;16(5):756-63.

Martinez-Agosto JA, Mikkola HK, Hartenstein V, Banerjee U. The hematopoietic stem cell and its niche: a comparative view. Genes Dev. 2007 Dec 1;21(23):3044-60.