Dr. Nalo Hamilton's research focuses on the discovery of biomarkers that influence ethnic variability in the development, progression and clinical outcome of women with breast cancer. The current focus of Hamilton's research is the mechanism of IGF-2 induced phosphorylation of the estrogen receptors and the occurrence of this event in breast cancer cells from women with estrogen-independent tumors.
Richardson AE, Hamilton N, Davis W, Brito C, De Leon D. Insulin-like growth factor-2 (IGF-2) activates estrogen receptor-alpha and -beta via the IGF-1 and the insulin receptors in breast cancer cells. Growth Factors. 2011 Apr;29(2-3):82-93. Epub 2011 Mar 16.
Tripathi MK, Misra S, Khedkar SV, Hamilton N, Irvin-Wilson C, Sharan C, Sealy L, Chaudhuri G. Regulation of BRCA2 gene expression by the SLUG repressor protein in human breast cells. J Biol Chem. 2005 Apr 29;280(17):17163-71. Epub 2005 Feb 24.
Sharan C, Hamilton NM, Parl AK, Singh PK, Chaudhuri G. Identification and characterization of a transcriptional silencer upstream of the human BRCA2 gene. Biochem Biophys Res Commun. 1999 Nov 19;265(2):285-90.