Ohyun Kwon, PhD

Ohyun Kwon, PhD

Professor, Department of Chemistry and Biochemistry
Member, Molecular Biology Institute



Scientific Interests

Dr. Ohyun Kwon's research interest lies in the development of new methodologies for organic transformations, target-oriented synthesis of biologically important natural compounds and diversity oriented synthesis of natural product-like molecules. Molecules thus built will be employed in the investigation of biologically significant processes.

Highlighted Publications

Cai L, Zhang K, Kwon O. Catalytic Asymmetric Total Synthesis of (-)-Actinophyllic Acid. J Am Chem Soc. 2016 Mar 16;138(10):3298-301. doi: 10.1021/jacs.6b00567. Epub 2016 Mar 4.

Shimizu H, Schredelseker J, Huang J, Lu K, Naghdi S, Lu F, Franklin S, Fiji HD, Wang K, Zhu H, Tian C, Lin B, Nakano H, Ehrlich A, Nakai J, Stieg AZ, Gimzewski JK, Nakano A, Goldhaber JI, Vondriska TM, Hajnoczky G, Kwon O, Chen JN. Mitochondrial Ca(2+) uptake by the voltage-dependent anion channel 2 regulates cardiac rhythmicity. Elife. 2015 Jan 15;4. doi: 10.7554/eLife.04801.

Chang JW, Zuhl AM, Speers AE, Niessen S, Brown SJ, Mulvihill MM, Fan YC, Spicer TP, Southern M, Scampavia L, Fernandez-Vega V, Dix MM, Cameron MD, Hodder PS, Rosen H, Nomura DK, Kwon O, Hsu KL, Cravatt BF. Selective inhibitor of platelet-activating factor acetylhydrolases 1b2 and 1b3 that impairs cancer cell survival. ACS Chem Biol. 2015 Apr 17;10(4):925-32. doi: 10.1021/cb500893q. Epub 2015 Jan 20.

Lu J, Yoshimura K, Goto K, Lee C, Hamura K, Kwon O, Tamanoi F. Nanoformulation of Geranylgeranyltransferase-I Inhibitors for Cancer Therapy: Liposomal Encapsulation and pH-Dependent Delivery to Cancer Cells. PLoS One. 2015 Sep 9;10(9):e0137595. doi: 10.1371/journal.pone.0137595. eCollection 2015.

Zimonjic DB, Chan LN, Tripathi V, Lu J, Kwon O, Popescu NC, Lowy DR, Tamanoi F. In vitro and in vivo effects of geranylgeranyltransferase I inhibitor P61A6 on non-small cell lung cancer cells. BMC Cancer. 2013 Apr 22;13:198. doi: 10.1186/1471-2407-13-198.