Otto Martinez-Maza, PhD
Dr. Otto Martinez-Maza's research focuses on immune dysfunction and cancer, as well as AIDS pathogenesis.
A major objective of Martinez-Maza's work over the last several years has been to define HIV infection-associated immune system changes that precede, and contribute to, AIDS-associated non-Hodgkin's B-cell lymphoma (AIDS-lymphoma). In recent work, elevated serum levels of several B cell-stimulatory cytokines, soluble cytokine receptors and miRNAs were seen in the years preceding the development of AIDS-lymphoma. In other work, Martinez-Maza's group examined the prognostic value of serum cytokines and soluble receptors measured post-AIDS-NHL diagnosis, and prior to the initiation of treatment, in studies done with the AIDS Malignancies Consortium (AMC).
Martinez-Maza is actively involved in several national and international multi-center studies of cancer or AIDS and HIV infection. He serves on the executive committees for the AMC and the Multi-center AIDS Cohort Study (MACS), is PI of the UCLA MACS site (joint with Dr. Roger Detels) and participates in Interlymph, an international consortium of researchers with an interest in the epidemiology and pathogenesis of lymphoma.
Epeldegui M, Lee JY, Martinez AC, Widney DP, Magpantay LI, Regidor D, Mitsuyasu R, Sparano JA, Ambinder RF, Martinez-Maza O. Predictive Value of Cytokines and Immune Activation Biomarkers in AIDS-Related Non-Hodgkin Lymphoma Treated with Rituximab plus Infusional EPOCH (AMC-034 trial). Clin Cancer Res. 2016 Jan 15;22(2):328-36. doi: 10.1158/1078-0432.CCR-14-0466. Epub 2015 Sep 17.
Thapa DR, Hussain SK, Tran WC, D'souza G, Bream JH, Achenback CJ, Ayyavoo V, Detels R, Martinez-Maza O. Serum microRNAs in HIV-infected individuals as pre-diagnosis biomarkers for AIDS-NHL. J Acquir Immune Defic Syndr. 2014 Jun 1;66(2):229-37. doi: 10.1097/QAI.0000000000000146.
Widney DP, Olafsen T, Wu AM, Kitchen CM, Said JW, Smith JB, Pena G, Magpantay LI, Penichet ML, Martinez-Maza O. Levels of murine, but not human, CXCL13 are greatly elevated in NOD-SCID mice bearing the AIDS-associated Burkitt lymphoma cell line, 2F7. PLoS One. 2013 Aug 2;8(8):e72414. doi: 10.1371/journal.pone.0072414. Print 2013.
Vendrame E, Hussain SK, Breen EC, Magpantay LI, Widney DP, Jacobson LP, Variakojis D, Knowlton ER, Bream JH, Ambinder RF, Detels R, Martinez-Maza O. Serum levels of cytokines and biomarkers for inflammation and immune activation, and HIV-associated non-Hodgkin B-cell lymphoma risk. Cancer Epidemiol Biomarkers Prev. 2014 Feb;23(2):343-9. doi: 10.1158/1055-9965.EPI-13-0714. Epub 2013 Nov 12.
De Roos AJ, Mirick DK, Edlefsen KL, LaCroix AZ, Kopecky KJ, Madeleine MM, Magpantay L, Martinez-Maza O. Markers of B-cell activation in relation to risk of non-Hodgkin lymphoma. Cancer Res. 2012 Sep 15;72(18):4733-43. Epub 2012 Jul 30.