Patrick G. Harran, PhD

Dr. Patrick G. Harran's laboratory studies the synthesis of small molecules that are potentially lead structures for cancer drug development. His lab explores the chemistry of both naturally occurring compounds and molecules of their own designs.

Ishika Saha, Eric K. Dang, Dennis Svatuneka, Kendall N. Houk, Patrick G. Harran. (2020) Computational Generation of an Annotated Gigalibrary of Synthesizable, Composite Peptidic Macrocycles Proc. Natl. Acad. Sci. (USA), 117, in press.

Tomoyuki Tsunemi, Salvador J. Bernadino, Angel Mendoza, Christopher G. Jones, Patrick G. Harran. (2020) Synthesis of atypically fluorinated peptidyl macrocycles via sequential vinylic substitutions Angew. Chem Intl. Ed. Engl., 59, 674-678.

Zhengao Feng, Tyler K. Allred, Evan E. Hurlow and Patrick G. Harran. (2019) Anomalous chromophore disruption enables an eight-step synthesis and stereochemical reassignment of (+)-marinesosin A. J. Am. Chem. Soc., 141(6): 2274-2278. PMID: 30691264; PMCID (in progress; Epub ahead of print)

Francesco Manoni, Corentin Rumo, Liubo Li and Patrick G. Harran. (2018) Unconventional fragment usage enables a concise total synthesis of (-)-callyspongiolide. J. Am. Chem. Soc., 140(4): 1280-1284. PMID: 29332397

Michal Wieczorek, Joseph Tcherkezian, Cynthia Bernier, Andrea E. Prota, Sami Chaaban, Yannève Rolland, Claude Godbout, Mark A. Hancock, Joseph C. Arezzo, Ozhan Ocal, Cecilia Rocha, Natacha Olieric, Anita Hall, Hui Ding, Alexandre Bramoullé, Matthew G. Annis, George Zogopoulos, Patrick G. Harran, Thomas M. Wilkie, Rolf. A. Brekken, Peter M. Siegel, Michel O. Steinmetz, Gordon C. Shore, Gary Brouhard and Anne Roulston (2016). The synthetic diazonamide DZ-2384 has distinct effects on microtubule curvature and dynamics without neurotoxicity. Science Transl. Med., 8, 365ra159. PMID27856798; PMCID: PMC5291303.