Dr. Philip Scumpia is particularly interested in how immune surveillance of the skin restrains skin carcinogenesis. As a dermatologist and dermatopathologist, his clinical interests include squamous cell carcinoma, melanoma and Merkel cell carcinoma, particularly in immunosuppressed organ transplant recipients who develop these cutaneous malignancies at a higher rate. As a researcher, his interests include identifying how cutaneous malignancies develop in organ transplant recipients and using immunoprofiling, transcriptional analysis and gene regulation principles to identify novel therapeutics that can treat cutaneous malignancies.
Flores A, Grant W, White AC, Scumpia P, Takahashi R, Lowry WE. Tumor suppressor identity can contribute to heterogeneity of phenotype in hair follicle stem cell-induced squamous cell carcinoma. Exp Dermatol. 2016 Sep;25(9):733-5. doi: 10.1111/exd.13037. Epub 2016 Jun 30.
Inkeles MS, Scumpia PO, Swindell WR, Lopez D, Teles RM, Graeber TG, Meller S, Homey B, Elder JT, Gilliet M, Modlin RL, Pellegrini M. Comparison of molecular signatures from multiple skin diseases identifies mechanisms of immunopathogenesis. J Invest Dermatol. 2015 Jan;135(1):151-9. doi: 10.1038/jid.2014.352. Epub 2014 Aug 11.
Cuenca AG, Cuenca AL, Winfield RD, Joiner DN, Gentile L, Delano MJ, Kelly-Scumpia KM, Scumpia PO, Matheny MK, Scarpace PJ, Vila L, Efron PA, LaFace DM, Moldawer LL. Novel role for tumor-induced expansion of myeloid-derived cells in cancer cachexia. J Immunol. 2014 Jun 15;192(12):6111-9. doi: 10.4049/jimmunol.1302895. Epub 2014 May 14.
White AC, Khuu JK, Dang CY, Hu J, Tran KV, Liu A, Gomez S, Zhang Z, Yi R, Scumpia P, Grigorian M, Lowry WE. Stem cell quiescence acts as a tumour suppressor in squamous tumours. Nat Cell Biol. 2014 Jan;16(1):99-107. doi: 10.1038/ncb2889. Epub 2013 Dec 15.