Rajan Singh, PhD
Research in Dr. Rajan Singh's laboratory focuses on understanding the mechanisms responsible for differential nitrosative and oxidative stress in triple negative (TN) breast tumors and identifying key molecular targets that could potentially be used for therapeutic purposes. Other areas of research include identifying key cell types that contribute to breast tumor initiation and progression and delineating their complex interplay with adipose rich tumor microenvironment of mammary gland.
Martinez L, Thames E, Kim J, Chaudhuri G, Singh R, Pervin S. Increased sensitivity of African American triple negative breast cancer cells to nitric oxide-induced mitochondria-mediated apoptosis. BMC Cancer. 2016 Jul 29;16:559. doi: 10.1186/s12885-016-2547-z.
Singh R, Parveen M, Basgen JM, Fazel S, Meshesha MF, Thames EC, Moore B, Martinez L, Howard CB, Vergnes L, Reue K, Pervin S. Increased Expression of Beige/Brown Adipose Markers from Host and Breast Cancer Cells Influence Xenograft Formation in Mice. Mol Cancer Res. 2016 Jan;14(1):78-92. doi: 10.1158/1541-7786.MCR-15-0151. Epub 2015 Oct 13.
Singh R, Avliyakulov NK, Braga M, Haykinson MJ, Martinez L, Singh V, Parveen M, Chaudhuri G, Pervin S. Proteomic identification of mitochondrial targets of arginase in human breast cancer. PLoS One. 2013 Nov 5;8(11):e79242. doi: 10.1371/journal.pone.0079242. eCollection 2013.
Pervin S, Tran L, Urman R, Braga M, Parveen M, Li SA, Chaudhuri G, Singh R. Oxidative stress specifically downregulates survivin to promote breast tumour formation. Br J Cancer. 2013 Mar 5;108(4):848-58. doi: 10.1038/bjc.2013.40. Epub 2013 Feb 12.
Pervin S, Hewison M, Braga M, Tran L, Chun R, Karam A, Chaudhuri G, Norris K, Singh R. Down-regulation of vitamin D receptor in mammospheres: implications for vitamin D resistance in breast cancer and potential for combination therapy. PLoS One. 2013;8(1):e53287. doi: 10.1371/journal.pone.0053287. Epub 2013 Jan 14. Erratum in: PLoS One. 2013;8(10). doi:10.1371/annotation/5326d117-3f31-4e43-a5c4-9e1fb41719e9.