Rene R. Sevag Packard, MD, PhD

Rene R.S. Packard, MD, PhD

Assistant Professor in Residence, Department of Medicine, Cardiology




Medicine/Cardiology/Cardiovascular Disease

Institutional Affiliation

Ronald Reagan UCLA Medical Center



Cardiovascular Disease, UCLA School of Medicine, 2011 - 2016


Internal Medicine, University Hospitals of Cleveland, Case Western Reserve University School of Medicine, 2010


PhD, UCLA Graduate Program in Molecular, Cellular and Integrative Physiology, 2016
MD, Faculty of Medicine, University of Geneva, Switzerland, 2004


Internal Medicine, University Hospitals of Cleveland, Case Western Reserve University School of Medicine, 2009 - 2011

Board Certifications

Cardiovascular Disease, American Board of Internal Medicine, 2016
Internal Medicine, American Board of Internal Medicine, 2015

Contact Information

Scientific Interests

A disease that remains incompletely understood is chemotherapy-induced cardiac injury and ensuing cardiomyopathy. Dr. Rene Packard's research scrutinizes the mechanical, architectural and molecular changes occurring in anthracycline-induced cardiac injury using doxorubicin as a study drug, to explore molecular imaging of candidate genes for the early and specific detection of cardiotoxicity and to modify regenerative pathways using pertinent genetic models.

Highlighted Publications

Chen J, Ding Y, Chen M, Gau J, Jen N, Nahal C, Tu S, Chen C, Zhou S, Chang CC, Lyu J, Xu X, Hsiai TK, Packard RRS. Displacement analysis of myocardial mechanical deformation (DIAMOND) reveals segmental susceptibility to doxorubicin-induced injury and regeneration. JCI Insight. 2019 Apr 18;4(8). pii: 125362. doi: 10.1172/jci.insight.125362. eCollection 2019 Apr 18.

Tuzovic M, Yang EH, Sevag Packard RR, Ganz PA, Fonarow GC, Ziaeian B. National Outcomes in Hospitalized Patients With Cancer and Comorbid Heart Failure. J Card Fail. 2019 Jul;25(7):516-521. doi: 10.1016/j.cardfail.2019.02.007. Epub 2019 Feb 12.

Ding Y, Dvornikov AV, Ma X, Zhang H, Wang Y, Lowerison M, Packard RR, Wang L, Chen J, Zhang Y, Hsiai T, Lin X, Xu X. Haploinsufficiency of mechanistic target of rapamycin ameliorates bag3 cardiomyopathy in adult zebrafish. Dis Model Mech. 2019 Oct 1;12(10). pii: dmm040154. doi: 10.1242/dmm.040154.

Packard RRS, Baek KI, Beebe T, Jen N, Ding Y, Shi F, Fei P, Kang BJ, Chen PH, Gau J, Chen M, Tang JY, Shih YH, Ding Y, Li D, Xu X, Hsiai TK. Automated Segmentation of Light-Sheet Fluorescent Imaging to Characterize Experimental Doxorubicin-Induced Cardiac Injury and Repair. Sci Rep. 2017 Aug 17;7(1):8603. doi: 10.1038/s41598-017-09152-x.