Shasha Chong, PhD

Shasha Chong, PhD

Assistant Professor of Chemistry, Division of Chemistry and Chemical Engineering, Caltech



Institutional Affiliation




Biophysics & Molecular and Cancer Biology, University of California at Berkeley, Berkeley, CA, 2021


PhD, Harvard University, Cambridge, MA, 2014
MA, Harvard University, Cambridge, MA, 2010
BS, University of Science and Technology of China, Hefei, P.R. China, 2008

Contact Information

Scientific Interests

Dr. Chong's lab develops new tools centering high-resolution optical imaging to understand the interaction behaviors of intrinsically disordered proteins and how they lead to transcriptional dysregulation in cancer. They study cancers including and beyond Ewing sarcoma, rhabdomyosarcoma, and acute myeloid leukemia.

Highlighted Publications

Wan, L.; Chong, S.; Xuan, F.; Liang, A.; Cui, X.; Gates, L.; Carroll, T.; Li, Y.; Feng, L.; Chen, G.; Wang, S.-P.; Ortiz, M.; Daley, S.; Wang, X.; Xuan, H.; Kentsis, A.; Muir, T.; Roeder, R. G.; Li, H.; Li, W.; Tjian, R.; Wen, H.; Allis, C. D. (2020) “Impaired cell fate by gain-of-function mutations in a chromatin reader” Nature, 577, 121-126.

Seong, B. K.; Dharia, N. V.; Lin, S.; Donovan, K. A.; Chong, S.; Robichaud, A.; Conway, A.; Hamze, A.; Ross, L.; Alexe, G.; Adane, B.; Nabet, B.; Ferguson, F.; Stolte, B.; Wang, E. J.; Sun, J.; Darzacq, X.; Piccioni, F.; Gray, N. S.; Fischer, E. S.; Stegmaier, K. (2021) “TRIM8 modulates the EWS/FLI oncoprotein to promote survival in Ewing sarcoma” Cancer Cell, 39, 1262-1278.

Chong, S.; Graham, T. G. W.; Dugast-Darzacq, C.; Dailey, G. M.; Darzacq, X.; Tjian, R. (2022) “Tuning levels of low-complexity domain interactions to modulate endogenous oncogenic transcription” Molecular Cell, 82, 2084-2097.

Wang, X. Q. D.; Fan, D.; Han, Q.; Liu, Y.; Miao, H.; Wang, X.; Li, Q.; Chen, D.; Gore, H.; Himadewi, P.; Pfeifer, G. P.; Cierpicki, T.; Grembecka, J.; Su, J.; Chong, S.† ; Wan, L.†; Zhang, X.† (2022) “Mutant NPM1 hijacks transcriptional hub to maintain pathogenic gene programs in acute myeloid leukemia” Cancer Discovery. †Corresponding author.

Chen, L.†; Zhang, Z.; Han, Q.; Rodrigues, L.; Zboril, E.; Adhikari, R.; Li, X.; Ko, S-H.; Xue, P.; Smith, E.; Xu, K., Wang, Q.; Huang, T.; Chong, S.†; Liu, Z.† (2022) “Hormone-induced enhancer assembly requires an optimal level of hormone receptor multivalent interactions” BioRxiv, 2022.10.28.514297. †Corresponding author