Dr. Timothy O'Sullivan's research focuses on circulating and tissue-resident innate lymphoid cell (ILC) responses during inflammation. This involves models of viral infection, diet-induced obesity, cancer immunoediting and metastasis. His lab is interested in understanding the role of tissue-resident ILC1 in cancer immunosurveillance and the mechanisms by which cancer escapes IFN-gamma mediated immune suppression.
Weizman OE, Adams NM, Schuster IS, Krishna C, Pritykin Y, Lau C, Degli-Esposti MA, Leslie CS, Sun JC, O'Sullivan TE. ILC1 Confer Early Host Protection at Initial Sites of Viral Infection. Cell. 2017 Nov 2;171(4):795-808.e12. doi: 10.1016/j.cell.2017.09.052. Epub 2017 Oct 19.
Saddawi-Konefka R, Seelige R, Gross ET, Levy E, Searles SC, Washington A Jr, Santosa EK, Liu B, O'Sullivan TE, Harismendy O, Bui JD. Nrf2 Induces IL-17D to Mediate Tumor and Virus Surveillance. Cell Rep. 2016 Aug 30;16(9):2348-58. doi: 10.1016/j.celrep.2016.07.075. Epub 2016 Aug 18.
O'Sullivan TE, Geary CD, Weizman OE, Geiger TL, Rapp M, Dorn GW 2nd, Overholtzer M, Sun JC. Atg5 Is Essential for the Development and Survival of Innate Lymphocytes. Cell Rep. 2016 May 31;15(9):1910-9. doi: 10.1016/j.celrep.2016.04.082. Epub 2016 May 19.
O'Sullivan T, Saddawi-Konefka R, Gross E, Tran M, Mayfield SP, Ikeda H, Bui JD. Interleukin-17D mediates tumor rejection through recruitment of natural killer cells. Cell Rep. 2014 May 22;7(4):989-98. doi: 10.1016/j.celrep.2014.03.073. Epub 2014 May 1.