Xinmin Li, PhD
Dr. Xinmin Li's research focuses on the identification and characterization of genetic variations that affect complex diseases. Li takes an integrated genomic approach to examine the alteration of mRNA/miRNA expression, copy number variation, single nucleotide polymorphism and DNA-protein interaction by primarily using microarray-based technologies for initial screening and siRNA-mediated knockdown technologies for functional screening. His goals are to identify clinically significant genetic variations in several widely prevalent diseases including cancer and obesity. One of his ongoing research projects is to study the microRNA regulation of adipocyte differentiation. Using the combination of gene array/miRNA array profiling, bioinformatics and siRNA knockdown, Li and his colleagues have found that miR-17-92, a miRNA cluster that promotes cell proliferation in various cancers, can accelerate adipocyte differentiation by directly targeting a tumor suppressor, Rb2/p130.
Li J, Yu B, Deng P, Cheng Y, Yu Y, Kevork K, Ramadoss S, Ding X, Li X, Wang CY. KDM3 epigenetically controls tumorigenic potentials of human colorectal cancer stem cells through Wnt/Beta-catenin signalling. Nat Commun. 2017 Apr 25;8:15146. doi: 10.1038/ncomms15146.
Wei W, Shin YS, Xue M, Matsutani T, Masui K, Yang H, Ikegami S, Gu Y, Herrmann K, Johnson D, Ding X, Hwang K, Kim J, Zhou J, Su Y, Li X, Bonetti B, Chopra R, James CD, Cavenee WK, Cloughesy TF, Mischel PS, Heath JR, Gini B. Single-Cell Phosphoproteomics Resolves Adaptive Signaling Dynamics and Informs Targeted Combination Therapy in Glioblastoma. Cancer Cell. 2016 Apr 11;29(4):563-73. doi: 10.1016/j.ccell.2016.03.012.
Dong L, Wang W, Li A, Kansal R, Chen Y, Chen H, Li X. Clinical Next Generation Sequencing for Precision Medicine in Cancer. Curr Genomics. 2015 Aug;16(4):253-63. doi: 10.2174/1389202915666150511205313.
Sun Y, Shi N, Lu H, Zhang J, Ma Y, Qiao Y, Mao Y, Jia K, Han L, Liu F, Li H, Lin Z, Li X, Zhao X. ABCC4 copy number variation is associated with susceptibility to esophageal squamous cell carcinoma. Carcinogenesis. 2014 Sep;35(9):1941-50. doi: 10.1093/carcin/bgu043. Epub 2014 Feb 7.
Wang Q, Li YC, Wang J, Kong J, Qi Y, Quigg RJ, Li X. miR-17-92 cluster accelerates adipocyte differentiation by negatively regulating tumor-suppressor Rb2/p130. Proc Natl Acad Sci U S A. 2008 Feb 26;105(8):2889-94. Epub 2008 Feb 19.