Xinshu (Grace) Xiao, PhD
Dr. Grace Xiao's group is interested in the regulation of gene expression at the RNA level via the process of pre-mRNA splicing and other post-transcriptional (or co-transcriptional) mechanisms. They are investigating how different sequence motifs and trans-acting regulatory RNA or proteins exert concerted regulation to gene expression and how such regulation is disrupted in disease processes. Their work makes use of high-throughput sequencing and microarray expression technologies and approaches in molecular biology and bioinformatics.
Hsiao YH, Bahn JH, Lin X, Chan TM, Wang R, Xiao X. Alternative splicing modulated by genetic variants demonstrates accelerated evolution regulated by highly conserved proteins. Genome Res. 2016 Apr;26(4):440-50. doi: 10.1101/gr.193359.115. Epub 2016 Feb 17.
Lin X, Lo HC, Wong DT, Xiao X. Noncoding RNAs in human saliva as potential disease biomarkers. Front Genet. 2015 May 7;6:175. doi: 10.3389/fgene.2015.00175. eCollection 2015.
Bahn JH, Ahn J, Lin X, Zhang Q, Lee JH, Civelek M, Xiao X. Genomic analysis of ADAR1 binding and its involvement in multiple RNA processing pathways. Nat Commun. 2015 Mar 9;6:6355. doi: 10.1038/ncomms7355.
Zhang Q, Xiao X. Genome sequence-independent identification of RNA editing sites. Nat Methods. 2015 Apr;12(4):347-50. doi: 10.1038/nmeth.3314. Epub 2015 Mar 2.
Xu Y, Gao XD, Lee JH, Huang H, Tan H, Ahn J, Reinke LM, Peter ME, Feng Y, Gius D, Siziopikou KP, Peng J, Xiao X, Cheng C. Cell type-restricted activity of hnRNPM promotes breast cancer metastasis via regulating alternative splicing. Genes Dev. 2014 Jun 1;28(11):1191-203. doi: 10.1101/gad.241968.114. Epub 2014 May 19.