The focus of Dr. Yibin Wang's lab is to reveal the genetic basis of stress-induced human diseases such as heart failure, metabolic disorders and cancer, and to discovery novel molecular and cellular mechanisms underlying the stress responses. The insights learned from stress-signaling regulation will lead to more mechanistic driven diagnosis and disease differentiation and to new effective therapies tailored to individuals. More specifically, Wang's lab aims to
- Discover novel components in stress signal transduction networks through systems genetic approach;
- Establish functional and molecular mechanisms mediating stress signaling pathways; and
- Translate mechanistic insights into novel therapies in disease models of heart failure, metabolic disorders and cancer.
Rau CD, Wang J, Avetisyan R, Romay MC, Martin L, Ren S, Wang Y, Lusis AJ. Mapping genetic contributions to cardiac pathology induced by Beta-adrenergic stimulation in mice. Circ Cardiovasc Genet. 2015 Feb;8(1):40-9. doi: 10.1161/CIRCGENETICS.113.000732. Epub 2014 Dec 5.
Lu G, Sun H, She P, Youn JY, Warburton S, Ping P, Vondriska TM, Cai H, Lynch CJ, Wang Y. Protein phosphatase 2Cm is a critical regulator of branched-chain amino acid catabolism in mice and cultured cells. J Clin Invest. 2009 Jun;119(6):1678-87. doi: 10.1172/JCI38151.
Lu G, Ren S, Korge P, Choi J, Dong Y, Weiss J, Koehler C, Chen JN, Wang Y. A novel mitochondrial matrix serine/threonine protein phosphatase regulates the mitochondria permeability transition pore and is essential for cellular survival and development. Genes Dev. 2007 Apr 1;21(7):784-96. Epub 2007 Mar 20.
Takimoto E, Champion HC, Li M, Belardi D, Ren S, Rodriguez ER, Bedja D, Gabrielson KL, Wang Y, Kass DA. Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses cardiac hypertrophy. Nat Med. 2005 Feb;11(2):214-22. Epub 2005 Jan 23.
Liao P, Georgakopoulos D, Kovacs A, Zheng M, Lerner D, Pu H, Saffitz J, Chien K, Xiao RP, Kass DA, Wang Y. The in vivo role of p38 MAP kinases in cardiac remodeling and restrictive cardiomyopathy. Proc Natl Acad Sci U S A. 2001 Oct 9;98(21):12283-8. Epub 2001 Oct 2.