Dr. Yvonne Chen's research focuses on applying molecular and synthetic biology techniques to rewire and construct novel biological circuits for applications in health and medicine, particularly in cell-based immunotherapy. Current projects include the engineering of next-generation chimeric antigen receptors and rewiring cytokine signaling pathways for adoptive T-cell therapy against cancer.
Ho P, Ede C, Chen YY. Modularly Constructed Synthetic Granzyme B Molecule Enables Interrogation of Intracellular Proteases for Targeted Cytotoxicity. ACS Synth Biol. 2017 Aug 18;6(8):1484-1495. doi: 10.1021/acssynbio.6b00392. Epub 2017 May 22.
Chang ZL, Chen YY. CARs: Synthetic Immunoreceptors for Cancer Therapy and Beyond. Trends Mol Med. 2017 May;23(5):430-450. doi: 10.1016/j.molmed.2017.03.002. Epub 2017 Apr 13. Review.
Zah E, Lin MY, Silva-Benedict A, Jensen MC, Chen YY. T Cells Expressing CD19/CD20 Bispecific Chimeric Antigen Receptors Prevent Antigen Escape by Malignant B Cells. Cancer Immunol Res. 2016 Jun;4(6):498-508. doi: 10.1158/2326-6066.CIR-15-0231. Epub 2016 Apr 8.
Chang ZL, Silver PA, Chen YY. Identification and selective expansion of functionally superior T cells expressing chimeric antigen receptors. J Transl Med. 2015 May 20;13:161. doi: 10.1186/s12967-015-0519-8.
Chen YY, Jensen MC, Smolke CD. Genetic control of mammalian T-cell proliferation with synthetic RNA regulatory systems. Proc Natl Acad Sci U S A. 2010 May 11;107(19):8531-6. doi: 10.1073/pnas.1001721107. Epub 2010 Apr 26.