Yvonne Y. Chen, PhD

Yvonne Y. Chen, PhD

Professor, Department of Microbiology, Immunology and Molecular Genetics



Contact Information

Scientific Interests

Dr. Yvonne Chen's research focuses on applying molecular and synthetic biology techniques to rewire and construct novel biological circuits for applications in health and medicine, particularly in cell-based immunotherapy. Current projects include the engineering of next-generation chimeric antigen receptors and rewiring cytokine signaling pathways for adoptive T-cell therapy against cancer.

Highlighted Publications

Ho P, Ede C, Chen YY. Modularly Constructed Synthetic Granzyme B Molecule Enables Interrogation of Intracellular Proteases for Targeted Cytotoxicity. ACS Synth Biol. 2017 Aug 18;6(8):1484-1495. doi: 10.1021/acssynbio.6b00392. Epub 2017 May 22.

Chang ZL, Chen YY. CARs: Synthetic Immunoreceptors for Cancer Therapy and Beyond. Trends Mol Med. 2017 May;23(5):430-450. doi: 10.1016/j.molmed.2017.03.002. Epub 2017 Apr 13. Review.

Zah E, Lin MY, Silva-Benedict A, Jensen MC, Chen YY. T Cells Expressing CD19/CD20 Bispecific Chimeric Antigen Receptors Prevent Antigen Escape by Malignant B Cells. Cancer Immunol Res. 2016 Jun;4(6):498-508. doi: 10.1158/2326-6066.CIR-15-0231. Epub 2016 Apr 8.

Chang ZL, Silver PA, Chen YY. Identification and selective expansion of functionally superior T cells expressing chimeric antigen receptors. J Transl Med. 2015 May 20;13:161. doi: 10.1186/s12967-015-0519-8.

Chen YY, Jensen MC, Smolke CD. Genetic control of mammalian T-cell proliferation with synthetic RNA regulatory systems. Proc Natl Acad Sci U S A. 2010 May 11;107(19):8531-6. doi: 10.1073/pnas.1001721107. Epub 2010 Apr 26.