UCLA SPORE in Prostate Cancer Developmental Research Program

The Development Research Program is another method of expanding discovery within the SPORE. Each year, three to four highly innovative proposals will be funded with the possibility of an additional year funding extension. Funding will be primarily for new and innovative ideas, but also to initiate short term collaborations, especially with investigators within the SPORE and in other SPORES. Sufficient expertise within the Institution or from interaction with other SPOREs must be demonstrated to show potential for development of a new major theme or research within the SPORE. The proposed projects need not be directly translational, but should have the potential to ultimately lead to translational research.

The UCLA SPORE in Prostate Cancer would like to congratulate all Developmental Research Program awardees. These projects come from various departments across campus, and exemplify translational research.

2022–2023 Awardees

Owen Witte, MD and Michael Jung, PhD
Project: Developing small molecule inhibitors of androgen receptor and Myc in prostate cancer

Leigh Ellis, PhD
Project: Novel mechanistic determination and actionable therapeutic targets for androgen indifferent castration-resistant prostate cancer

Amar Kishan, MD
Project: Transcriptomic Biomarkers of Extraprostatic Spread and Genomics of Radiorecurrent Prostate Cancer: Implications for Treatment Intensification

Dino DiCarlo, PhD and Owen Witte, MD
Project: Multi-parametric isolation of T cells targeting prostatic acid phosphatase for immunotherapy development

2021–2022 Awardees

Paul Boutros, PhD, MBA
Project: Expanding the Prostate Cancer Proteome: Identity & Function of Non-Canonical ORFs

Huihui Ye, MD
Project: Identification of the Key Immune Inhibitory Molecules in "Hot" Prostate Cancer of African American Men, a Spatial Transcriptomic Approach

Leigh Ellis, PhD
Project: Novel mechanistic determination and actionable therapeutic targets for androgen indifferent castration-resistant prostate cancer

2020–2021 Awardees

Paul Boutros, PhD, MBA
Project: Expanding the Prostate Cancer Proteome: Identity & Function of Non-Canonical ORFs

Huihui Ye, MD
Project: Identification of the Key Immune Inhibitory Molecules in "Hot" Prostate Cancer of African American Men, a Spatial Transcriptomic Approach

Leigh Ellis, PhD
Project: Novel mechanistic determination and actionable therapeutic targets for androgen indifferent castration-resistant prostate cancer

John Wilson Phillips, MD, PhD
Project: Targeting Alternative Pre-mRNA Splicing in Small Cell Prostate Cancers

Dino Di Carlo, PhD
Project: AR-V7 Protein Liquid Biopsy in Metastatic Castration Resistant Prostate Cancer

Neil Lin, PhD
Project: A High-Throughput 3D Spheroid Platform for Prostate Cancer Therapy Screening

Minna Lee, MD
Project: Defining Similarities and Differences of Advanced, Highly Aggressive Prostate and Breast Cancer

William Hsu, PhD
Project: Computational Framework for Discovering and Validating Imaging Endotypes to Predict Clinically Significant Prostate Cancer Aggressiveness

Robert Reiter, MD, MBA
Project: High Throughput of Screening of Small Molecule Inhibitors for Neuroendocrine Prostate

Past Awardees

For a complete list of all past awardees, view or download: PDF