Amander Clark, PhD
Dr. Amander Clark is interested in characterizing molecular programs unique to stem cells. She discovered a locus of genes on human chromosome 12p13 that are specifically expressed in human embryonic stem cells, germ cells and cancer cells. However, the mechanism of these genes in regulating cell biology is almost completely unknown. Her research seeks to understand the molecular mechanisms by which these genes regulate cell biology and to determine the utility of these genes as tumor biomarkers or possibly cancer therapeutics.
Diaz Perez SV, Kim R, Li Z, Marquez VE, Patel S, Plath K, Clark AT. Derivation of new human embryonic stem cell lines reveals rapid epigenetic progression in vitro that can be prevented by chemical modification of chromatin. Hum Mol Genet. 2012 Feb 15;21(4):751-64. Epub 2011 Nov 4
Gossett DR, Tse HT, Lee SA, Ying Y, Lindgren AG, Yang OO, Rao J, Clark AT, Di Carlo D. Hydrodynamic stretching of single cells for large population mechanical phenotyping. Proc Natl Acad Sci U S A. 2012 May 15;109(20):7630-5. Epub 2012 Apr 30
Ambartsumyan G, Gill RK, Perez SD, Conway D, Vincent J, Dalal Y, Clark AT. Centromere protein A dynamics in human pluripotent stem cell self-renewal, differentiation and DNA damage. Hum Mol Genet. 2010 Oct 15;19(20):3970-82. Epub 2010 Jul 22
Chodavarapu RK, Feng S, Bernatavichute YV, Chen PY, Stroud H, Yu Y, Hetzel JA, Kuo F, Kim J, Cokus SJ, Casero D, Bernal M, Huijser P, Clark AT, Kramer U, Merchant SS, Zhang X, Jacobsen SE, Pellegrini M. Relationship between nucleosome positioning and DNA methylation. Nature. 2010 Jul 15;466(7304):388-92. Epub 2010 May 30
Xie W, Song C, Young NL, Sperling AS, Xu F, Sridharan R, Conway AE, Garcia BA, Plath K, Clark AT, Grunstein M. Histone h3 lysine 56 acetylation is linked to the core transcriptional network in human embryonic stem cells. Mol Cell. 2009 Feb 27;33(4):417-27.