Dr. Anthony Wang's research focus is on designing and translating rational combinatorial strategies into clinical trials specifically for pediatric brain tumors. Researchers are only now beginning to understand the unique nature of many of these pediatric brain tumor types, and so Wang's laboratory explores many different aspects of these entities. Ongoing projects include development of animal models that reflect the molecular genetic characteristics of these tumors, multi-modal immunotherapeutic strategies that target these specific characteristics and epigenetic mechanisms of treatment resistance.
Antonios JP, Soto H, Everson RG, Moughon DL, Wang AC, Orpilla J, Radu C, Ellingson BM, Lee JT, Cloughesy T, Phelps ME, Czernin J, Liau LM, Prins RM. Detection of immune responses after immunotherapy in glioblastoma using PET and MRI. Proc Natl Acad Sci U S A. 2017 Sep 19;114(38):10220-10225. doi: 10.1073/pnas.1706689114. Epub 2017 Sep 5.
Mochizuki AY, Frost IM, Mastrodimos MB, Plant AS, Wang AC, Moore TB, Prins RM, Weiss PS, Jonas SJ. Precision Medicine in Pediatric Neurooncology: A Review. ACS Chem Neurosci. 2018 Jan 17;9(1):11-28. doi: 10.1021/acschemneuro.7b00388. Epub 2017 Dec 27.
Wang AC, Owen JH, Abuzeid WM, Hervey-Jumper SL, He X, Gurrea M, Lin M, Altshuler DB, Keep RF, Prince ME, Carey TE, Fan X, McKean EL, Sullivan SE. STAT3 Inhibition as a Therapeutic Strategy for Chordoma. J Neurol Surg B Skull Base. 2016 Dec;77(6):510-520. Epub 2016 May 31.
Ji M, Lewis S, Camelo-Piragua S, Ramkissoon SH, Snuderl M, Venneti S, Fisher-Hubbard A, Garrard M, Fu D, Wang AC, Heth JA, Maher CO, Sanai N, Johnson TD, Freudiger CW, Sagher O, Xie XS, Orringer DA. Detection of human brain tumor infiltration with quantitative stimulated Raman scattering microscopy. Sci Transl Med. 2015 Oct 14;7(309):309ra163. doi: 10.1126/scitranslmed.aab0195.