Christopher Seet, MD, PhD
Dr. Christopher Seet is a physician scientist whose research focuses on human immune cell developmentÑin particular, T-cell development from hematopoietic and pluripotent stem cells and the development of stem cell-derived engineered cell therapies for cancer. His lab also is interested in the characterization of new tumor?associated antigens and antigen-specific T-cell receptors for the development of new cellular immunotherapy approaches for cancers. Seet is also a clinical hematologist/oncologist who specializes in hematologic malignancies, bone marrow transplantation and cell therapies.
Montel-Hagen A, Seet CS, Li S, Chick B, Zhu Y, Chang P, Tsai S, Sun V, Lopez S, Chen HC, He C, Chin CJ, Casero D, Crooks GM. Organoid-Induced Differentiation of Conventional T Cells from Human Pluripotent Stem Cells. Cell Stem Cell. 2019 Mar 7;24(3):376-389.e8. doi: 10.1016/j.stem.2018.12.011. Epub 2019 Jan 17.
Seet CS, He C, Bethune MT, Li S, Chick B, Gschweng EH, Zhu Y, Kim K, Kohn DB, Baltimore D, Crooks GM, Montel-Hagen A. Generation of mature T cells from human hematopoietic stem and progenitor cells in artificial thymic organoids. Nat Methods. 2017 May;14(5):521-530. doi: 10.1038/nmeth.4237. Epub 2017 Apr 3.