Dr. Erina Vlashi's laboratory has made the unique discovery that cancer stem cells (CSCs) have low proteasome activity. They can exploit this feature to identify, track and target CSCs, and to explore important questions about CSCs, such as their radiobiology, metabolic characteristics and the factors involved in the ability of non-CSCs to reprogram into CSCs.
Vlashi E, Chen AM, Boyrie S, Yu G, Nguyen A, Brower PA, Hess CB, Pajonk F. Radiation-Induced Dedifferentiation of Head and Neck Cancer Cells Into Cancer Stem Cells Depends on Human Papillomavirus Status. Int J Radiat Oncol Biol Phys. 2016 Apr 1;94(5):1198-206. doi: 10.1016/j.ijrobp.2016.01.005. Epub 2016 Jan 14.
Vlashi E, Lagadec C, Vergnes L, Reue K, Frohnen P, Chan M, Alhiyari Y, Dratver MB, Pajonk F. Metabolic differences in breast cancer stem cells and differentiated progeny. Breast Cancer Res Treat. 2014 Aug;146(3):525-34. doi: 10.1007/s10549-014-3051-2. Epub 2014 Jul 10.
Lagadec C, Vlashi E, Della Donna L, Dekmezian C, Pajonk F. Radiation-induced reprogramming of breast cancer cells. Stem Cells. 2012 May;30(5):833-44. doi: 10.1002/stem.1058.
Vlashi E, Lagadec C, Vergnes L, Matsutani T, Masui K, Poulou M, Popescu R, Della Donna L, Evers P, Dekmezian C, Reue K, Christofk H, Mischel PS, Pajonk F. Metabolic state of glioma stem cells and nontumorigenic cells. Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):16062-7. doi: 10.1073/pnas.1106704108. Epub 2011 Sep 7.
Vlashi E, Kim K, Lagadec C, Donna LD, McDonald JT, Eghbali M, Sayre JW, Stefani E, McBride W, Pajonk F. In vivo imaging, tracking, and targeting of cancer stem cells. J Natl Cancer Inst. 2009 Mar 4;101(5):350-9. doi: 10.1093/jnci/djn509. Epub 2009 Feb 24.